The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care Study

A multi-centre randomised controlled trial to evaluate whether early jejunal feeding increases energy delivery in critically ill patients

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000149662

Acronym

The ENTERIC Study

Enrollment

181

Registered

2005-08-15

Start date

2006-01-30

Completion date

2009-04-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

study completed and published Conclusions: In mechanically ventilated patients with mildly elevated gastric residual volumes and already receiving nasogastric nutrition, early nasojejunal nutrition did not increase energy delivery and did not appear to reduce the frequency of pneumonia. The rate of minor gastrointestinal hemorrhage was increased. Routine placement of a nasojejunal tube in such patients is not recommended.

Interventions

Early jejunal feeding (using a frictional NJ tube).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

ICU patients are eligible for enrolment if they meet all of the following: in ICU for less than 48 hours prior to enrolment, receiving invasive mechanical ventilation (through an endotracheal tube or tracheostomy, NOT a facemask) with an anticipated need for more than 48 hours of mechanical ventilation, receiving a continuous infusion of any one of morphine (>2mg/hour, fentanyl (> 20mcg/hour), or pethidine (>20mg/hour), either a single GRV > 150mls (whilst receiving EN via an NG tube, or nasogastic drainage >500mls over 12 hours (whether receiving EN or not).

Exclusion criteria

Patients will be ineligible for enrolment if they meet any of the following criteria: previous or recent surgery which has altered the anatomy of the gastrointestinal tract (eg. oesophagectomy, gastrectomy, any gastric anastomosis surgery, gastroplasty, pyloroplasty, pancreaticoduodenectomy (Whipple's procedure), known gastric malignancy, known oesophageal varices, current admission for peptic ulceration, current mechanical bowel obstruction, current gastostomy, jejunostomy, or surgically placed enteral tube in situ, contraindication to the use of the nose and mouth for enteral tube insertion (eg recent facial trauma or surgery), receiving nutritional support prior to ICU admission, severe coagulopathy (defined by platelet count <20 and/or INR>4.0).

Outcome results