Skip to content

The DRIP Trial

A randomised phase III study to evaluate the effects of changing peripheral intravenous cannulas when clinically indicated to reduce the rate of cannula related complications

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12605000147684
Acronym
The DRIP Trial
Enrollment
754
Registered
2005-08-15
Start date
2006-02-22
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Most hospitals re-site peripheral intravenous catheters in adults every 72-96 hours, based on current Centers of Disease Control and Prevention Guidelines. This is at odds with regimes for children, and critically ill patients, where cannulas are only re-sited when clinically indicated. Recent prospective surveillance studies have demonstrated the safety of longer dwell times but these observations have not been validated in adults, using randomised controlled trial methodology. The primary aim of the present study is to compare the rates of peripheral catheter-related local infection, phlebitis and obstruction between two groups of patients - those having routine catheter changes every 72 hours and those having catheter changes only when clinically indicated.

Interventions

Intervention: Cannula re-sited when clinically indicated

Sponsors

Joan Webster
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. they are inpatients at the Royal Brisbane and Women's Hospital. 2. They are scheduled or expected to have a peripheral venous catheter indwelling for at least 4 days.

Exclusion criteria

1. Patients with an existing bloodstream infection 2. Those receiving immunosupressive treatment.

Outcome results

None listed

Source: ANZCTR · Data processed: Apr 5, 2026