None listed
Conditions
Interventions
To determine the effect of acute circadian disruption (simulated jet-lag-2 days) on a range of neurobehavioural and physiological variables in patients with obstructive sleep apnea or asthma.
Sponsors
Woolcock Institute of Medical Research
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
OSA: Untreated subjects with moderate to severe OSA (RDI > 30). Asthma: Asthmatic subjects (ATS Criteria) will be recruited from asthma clinics associated with AIs. We will use clinic patients (current non-smokers and minimal smoking history)with moderate to severe asthma based on NAC guidelines i.e. those requiring short acting beta agonists 3 or more days week or with nocturnal symptoms more than once per fortnight. Controls: We will recruit healthy controls.
Exclusion criteria
OSA: use of alcohol> 40gm/day, psychotropic medication, intercurrent asthma, other unstable medical conditions or evidence of clinically significant awake respiratory failure. Asthma:We will exclude subjects on long-acting bronchodilators (salmeterol, formoterol, tiotropium and theophylline). Inhaled corticosteroids will be held constant from screening into studies and use of short acting beta agonists will be permitted and monitored during protocols. Controls: similar exclusion criteria as for the OSA and asthma subjects Subjects with the presence of asthma (ATS criteria) and OSA will be excluded. The absence of OSA will be determined using a validated nocturnal respiratory monitor over 2 nights (Autoset T, ResMed).
Outcome results
None listed