Does a single oral dose of dexamethasone after successful emergency department treatment of migraine reduce the incidence or severity of rebound headache within 48 hours?

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000034639

Enrollment

Registered

2005-07-22

Start date

2005-01-04

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

The primary aim is to compare the proportion of patients who experience rebound headache within 48 hours after ED treatment of migraine between a group treated with single dose oral dexamethasone 8mg and a group treated with placebo.Secondary aims are to compare headache severity, analgesia/ health service use, adverse events and return to normal functioning between the groups.

Study design

Allocation

Randomised controlled trial

Intervention model

Factorial

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

17 Years to No maximum

Healthy volunteers

Inclusion criteria

Consenting adult patients with physician-diagnosed migraine treated in the ED who are willing and able to be contacted between 48-72 hours after discharge for follow-up.

Exclusion criteria

Failure to consent. Pregnancy. Allergy to study medication. Findings inconsistent with migraine. Patients requiring hospital admission for further investigation and treatment. Patients with active peptic ulcer disease. Patients with Type 1 diabetes. Patients taking corticosteroids for another condition within 7 days. Active systemic fungal infection. Patients previously enrolled in the study

Outcome results