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Comparitive Rehydration in Bronchiolitis

A prospective randomized trial comparing nasogastric with intravenous rehydration in children with bronchiolitis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12605000033640
Acronym
CRIB
Enrollment
750
Registered
2005-07-22
Start date
2009-05-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The need for supplying fluids in paediatric bronchiolitis (severe viral airway infection of the infant) is frequent, and is the consequence of reduced feeding, sweating, and fever., There are currently 2 means of supplying fluids, intravenous or nasogastric. Nasogastric rehydration (NR) means giving fluids through a feeding tube inserted through the nostrils into the stomach thus eliminating the effort of drinking. It is generally effective and has few complications. Intra venous rehydration (IR) means giving fluids directly into a vein through a drip. It is often difficult to insert a drip in this particular age group, whereas the nasal feeding tube is generally easier to insert. The potential complications of IR are water overload and electrolyte imbalances. The main possible complications of NR is vomiting. The role of NR in bronchiolitis is, however, controversial. It is, for example, an accepted treatment in Scandinavia and Switzerland, whereas IR is the accepted treatment at the RCH Melbourne. Even within Australia there is no standard of care as such among the different hospitals with most hospitals using a combination of NR and IR, without any guidelines. The little existing evidence shows that NR in bronchiolitis is safe and well tolerated. The major concern raised with NR is the partial obstruction of the airway, by cousing ablockage of the nostril in young children who mostly breathe through the nose, thus theoretically causing further breathing problems. But its clinical significance, especially in bronchiolitis, is not clear and has not been the subject of clinical trials. In this prospective study we will compare Nasogastric and Intravenous treatment in bronchiolitis.

Interventions

Open randomised trial comparing nasogastric and intravenous hydration in children under 1 year of age with bronchiolitis.

Sponsors

National Health and Medical Research Council
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
8 Weeks to 12 Months
Healthy volunteers
No

Inclusion criteria

1 Age more than 8 weeks (corrected for prematurity) and less than 12 months. 2 With symptoms of bronchiolitis as defined by respiratory distress (tachypnoea, recessions, nasal flaring etc.) due to acute viral respiratory tract infection. 3 Requiring hydration.

Exclusion criteria

1 Chronic respiratory disease. 2 Choanal atresia. 3 Severe dehydration (needing iv resuscitation). 4 Need of immediate ventilatory support. 5 Increased respiratory effort (severe recessions) and hypoxaemia (SaO2 <90% in >30% FiO2, or >2l/min O2). 6 Reasons for needing iv access other than bronchiolitis (investigations, medication).

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 31, 2026