Does Lowering Homocysteine slow the rate of memory loss in healthy older people?

The Effect of Homocysteine Lowering Vitamins on Cognitive Performance in healthy older people: a Randomised Controlled Trial

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000030673

Enrollment

260

Registered

2005-07-22

Start date

2002-09-04

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

A randomised, double-blind, placebo-controlled trial. Participants >= 65 years of age with total plasma homocysteine concentrations >=13 [micro]mol/L, and normal renal function were randomised to take a single capsule once daily, containing either a placebo (cellulose) or a combination of 1mg L-Mefolinic acid (folate), 0.5 mg cyanocobalamin and 10mg pyridoxol, over 2 years.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

Total plasma homocysteine concentration >= 13 [micro]mol/L; not taking supplementary folic acid or vitamins B-12 or B-6; no prior stroke; not diabetic; no established dementia; not taking folate inhibiting medications (antiepileptics, oral hypoglycaemics, treatment for depression); have normal renal function (creatinine clearance <133 [micro]mol/L in men and < 115 [micro]mol/L in women); availble for at least 2 years.

Exclusion criteria

No exclusion criteria

Outcome results