Does early whooping cough (pertussis) vaccination provide earlier antibody protection for infants?

Does early whooping cough (pertussis) vaccination provide earlier antibody protection for infants? A pilot study to determine the appropriate design for a trial of acellular pertussis vaccine given at birth?

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000013662

Enrollment

Registered

2005-07-18

Start date

2005-04-11

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In this study the antibody response (immunity) to pertussis vaccination will be compared in 3 groups, those who have routine pertussis vaccination commmencing at 2 months old with those who have received pertussis vaccines at birth and 1 month old or only birth.

Interventions

Group 1 - pertussis vaccination at birth and 1 month old followed by routine vaccination Group 2 - pertussis vaccination at birth followed by routine vaccination

Study design

Allocation

Randomised controlled trial

Intervention model

Factorial

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to 5 Days

Healthy volunteers

Inclusion criteria

Healthy Newborns less than 5 days old and born after 37 weeks gestation

Exclusion criteria

Serious chronic illness or immunodeficiency

Outcome results