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ZYTIGA 500 mg film-coated tablets

DRUG8 trials

Sponsors

UZ Leuven, AstraZeneca AB, Bayer Consumer Care AG, Bayer AG, Aragon Pharmaceuticals Inc., Jiangsu Hengrui Pharmaceuticals Co. Ltd.

Conditions

Castration-Resistant Prostate CancerMetastatic Castration-Resistant Prostate CancerMetastatic Castration-Sensitive Prostate Cancer (mCSPC)Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)Metastatic Prostate CancerOligoprogressive metastatic castration-refractory prostate cancerProstate Cancermetastatic castrate resistant prostate cancer (mCRPC)

Phase 1

Phase 3

Metastasis-directed therapy in oligoprogressive castration-refractory prostate cancer: a randomized phase 3 trial
RecruitingCTIS2022-502254-13-00
UZ LeuvenOligoprogressive metastatic castration-refractory prostate cancer
Start: 2023-12-18Target: 246Updated: 2025-07-18
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Study of ARN-509 in Men with Non-Metastatic (M0) Castration-Resistant Prostate Cancer
Active, not recruitingCTIS2023-509221-47-00
Aragon Pharmaceuticals Inc.Castration-Resistant Prostate Cancer
Start: 2014-02-12Target: 30Updated: 2025-12-09
A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination with Physician’s Choice New Hormonal Agents in Patients with HRRm and non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01).
RecruitingCTIS2023-504214-30-00
AstraZeneca ABMetastatic Castration-Sensitive Prostate Cancer (mCSPC)
Start: 2024-06-27Target: 540Updated: 2025-11-13
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined with Abiraterone Acetate and Prednisone (AA-P) versus Placebo Combined with AA-P as First-Line Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer
Active, not recruitingCTIS2023-509396-16-00
Jiangsu Hengrui Pharmaceuticals Co. Ltd.Metastatic Castration-Resistant Prostate Cancer
Start: 2021-11-08Target: 136Updated: 2025-12-05
A Randomised, Double-blind, Placebo-controlled, Phase III Study of Adjuvant Saruparib (AZD5305) in Patients with BRCAm Localised High-risk Prostate Cancer Receiving Radiotherapy with Androgen Deprivation Therapy (EvoPAR-Prostate02)
RecruitingCTIS2024-513586-39-00
AstraZeneca ABProstate Cancer
Start: 2025-12-10Target: 253Updated: 2026-01-08
A Randomised, Double‑Blind, Placebo‑Controlled, 2‑Cohort, Phase III Study of Saruparib Combined with Physician’s Choice of Androgen Receptor Pathway Inhibitor in Patients With Metastatic Hormone‑Sensitive Prostate Cancer, Previously Treated With Docetaxel or PSMA‑directed 177Lutetium‑Containing Therapy Without Disease Progression, and With Prostate‑Specific Antigen ≥ 0.2 ng/mL: EvoPAR Prostate‑05
Not yet recruitingCTIS2026-526275-38-00
AstraZeneca ABMetastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Target: 176Updated: 2026-10-27

Phase 4

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