Zotatifin

DRUG3 trials

Sponsors

Effector Therapeutics, Jennifer Lee Caswell-Jin, M.D. Anderson Cancer Center

Conditions

Advanced TNBCBreast CancerCorona Virus InfectionEIF4AER Positive Breast CancerHER2-negative Breast CancerPhase IBPlatinum Helix Inhibition

Phase 1

Intravenous Zotatifin in Adults With Mild or Moderate COVID-19

CompletedNCT04632381

Effector TherapeuticsCorona Virus Infection

Start: 2021-07-01End: 2023-09-22Updated: 2023-10-05

Zotatifin And EIF4A Platinum Helix Inhibition In Resistant AdvancedTNBC

Not yet recruitingNCT07783659

M.D. Anderson Cancer CenterAdvanced TNBC, EIF4A, Phase IB +2

Start: 2027-02-12End: 2032-06-30Target: 24Updated: 2026-09-08

Phase 2

Umbrella Trial of Subtype-Targeted Therapies in ER+/HER2- Breast Cancer

CompletedNCT05101564

Jennifer Lee Caswell-JinBreast Cancer, ER Positive Breast Cancer, HER2-negative Breast Cancer

Start: 2023-03-20End: 2024-06-03Updated: 2026-02-12