Zongertinib
Sponsors
Boehringer Ingelheim
Conditions
Colorectal CancerEsophageal AdenocarcinomaGastroesophageal Junction AdenocarcinomaHealthyLung Cancer, Non-squamous, Non-small CellMetastatic Breast CancerMetastatic Gastric AdenocarcinomaNeoplasm Metastasis
Phase 1
Beamion LUNG-1: A Study to Test Different Doses of Zongertinib in People With Different Types of Advanced Cancer (Solid Tumours With Changes in the HER2 Gene)
Active, not recruitingNCT04886804
Start: 2021-07-02End: 2028-08-30Target: 554Updated: 2026-08-20
A Study in Healthy Men to Test How Itraconazole Influences the Amount of Zongertinib (BI 1810631) in the Blood
CompletedNCT05833139
Start: 2023-04-14End: 2023-06-12Updated: 2025-09-22
A Study in Healthy Men to Test How Zongertinib (BI 1810631) is Taken up and Processed by the Body
CompletedNCT05879991
Start: 2023-08-10End: 2023-10-19Updated: 2025-10-06
A Study in Healthy Men to Test Whether Carbamazepine Influences the Amount of Zongertinib in the Blood
CompletedNCT06028464
Start: 2023-09-11End: 2023-12-08Updated: 2025-11-05
A Study in Healthy Men to Test How Zongertinib is Taken up in the Body When Taken With or Without Food
CompletedNCT06075277
Start: 2023-10-19End: 2024-01-02Updated: 2025-09-22
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
RecruitingNCT06324357
Start: 2024-06-28End: 2029-01-08Target: 768Updated: 2026-09-16
A Study in Healthy Men to Test Whether Zongertinib Affects How 3 Other Medicines (Midazolam, Omeprazole, and Repaglinide) Are Taken up and Processed by the Body
CompletedNCT06494761
Start: 2024-07-30End: 2024-10-16Updated: 2025-12-02
A Study in Healthy Men to Test Whether Zongertinib Influences the Amount of 4 Other Medicines (Dabigatran, Rosuvastatin, Metformin, and Furosemide) in the Blood
CompletedNCT06504862
Start: 2024-08-20End: 2024-12-18Updated: 2026-01-09
A Study in Healthy Men to Test How Bosentan Influences the Amount of Zongertinib in the Blood
CompletedNCT07649941
Start: 2026-06-22End: 2026-08-24Updated: 2026-09-04
Phase 2
Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations
RecruitingNCT06581432
Start: 2024-10-11End: 2028-12-29Target: 588Updated: 2026-09-15
Beamion 44: A Study to Test How Well Zongertinib is Tolerated by People With Advanced Non-small Cell Lung Cancer With HER2 Mutations When Given in Combination With Chemotherapy With or Without Pembrolizumab
RecruitingNCT07486817
Start: 2026-06-04End: 2029-08-25Target: 60Updated: 2026-09-01
Phase 3
Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment
Active, not recruitingNCT06151574
Start: 2024-02-09End: 2028-01-28Updated: 2026-08-20
Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations
RecruitingNCT07195695
Start: 2026-01-16End: 2036-09-02Target: 400Updated: 2026-09-17
Related Papers
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