Zirabev 25 mg/ml concentrate for solution for infusion.
Sponsors
Immunogen Inc., Centre Hospitalier Universitaire De Grenoble, Enterome, ETOP IBCSG Partners Foundation, Universitaetsklinikum Regensburg AöR
Conditions
GlioblastomaPatients with EGFR-mutant (L858R or del19 only) advanced non-squamous NSCLCPatients with unresectablePlatinum-sensitive epithelial ovarianRefractory Metastatic Colorectal Cancer with Liver Dominant Diseasefallopian tubenon-squamous nonsmall-cell lung cancer (NSCLC) metastatic to the brainor primary
peritoneal cancers
Phase 1
Phase 2
Ezurpimtrostat autophagy inhibitor in association with Atezolizumab-Bevacizumab in first line treatment of unresectable hepatocellular carcinoma, a phase 2b randomized trial. ABE-LIVER
CompletedCTIS2022-502078-17-00
Start: 2022-12-15End: 2024-03-08Target: 196Updated: 2023-08-22
Breaking the big Five Barriers of Brain Metastasis:
A prospective phase II, open-label, multi-center trial of combined nivolumab, ipilimumab and bevacizumab together with 2 cycles of induction chemotherapy in patients with non-squamous non-small-cell lung cancer (NSCLC) metastatic to the brain
CA209-7WF / Break B5-BM-NSCLC
Active, not recruitingCTIS2024-512684-31-00
Start: 2021-04-14Target: 39Updated: 2025-12-05
ETOP 18-21 AMAZE-lung: A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI.
Active, not recruitingCTIS2024-512288-29-00
Start: 2023-04-11Target: 30Updated: 2025-06-06
An Open-label, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of Induction Treatment with Melphalan/HDS Followed by Consolidation Treatment with Trifluridine–tipiracil plus Bevacizumab Versus Trifluridine–tipiracil plus Bevacizumab Alone in Patients with Refractory Metastatic Colorectal Cancer with Liver Dominant Disease
RecruitingCTIS2024-520356-24-00
Start: 2025-12-01Target: 35Updated: 2025-11-21
Phase 3
2022-501606-35-00 – Randomized, multicenter, open-label, Phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-high recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancers who have not progressed after second-line platinum-based chemotherapy plus bevacizumab (GLORIOSA).
RecruitingCTIS2022-501606-35-01
Start: 2024-02-21Target: 110Updated: 2026-01-21
A randomized phase III trial with lomustine versus lomustine and bevacizumab for patients with recurrent glioblastoma
Not yet recruitingCTIS2024-519437-27-02
Target: 168Updated: 2025-01-13