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Zirabev 25 mg/ml concentrate for solution for infusion.

DRUG7 trials

Sponsors

Immunogen Inc., Centre Hospitalier Universitaire De Grenoble, Enterome, ETOP IBCSG Partners Foundation, Universitaetsklinikum Regensburg AöR

Conditions

GlioblastomaPatients with EGFR-mutant (L858R or del19 only) advanced non-squamous NSCLCPatients with unresectablePlatinum-sensitive epithelial ovarianRefractory Metastatic Colorectal Cancer with Liver Dominant Diseasefallopian tubenon-squamous nonsmall-cell lung cancer (NSCLC) metastatic to the brainor primary peritoneal cancers

Phase 1

Phase 2

Ezurpimtrostat autophagy inhibitor in association with Atezolizumab-Bevacizumab in first line treatment of unresectable hepatocellular carcinoma, a phase 2b randomized trial. ABE-LIVER
CompletedCTIS2022-502078-17-00
Centre Hospitalier Universitaire De Grenobleunresectable hepatocellular carcinoma
Start: 2022-12-15End: 2024-03-08Target: 196Updated: 2023-08-22
Breaking the big Five Barriers of Brain Metastasis: A prospective phase II, open-label, multi-center trial of combined nivolumab, ipilimumab and bevacizumab together with 2 cycles of induction chemotherapy in patients with non-squamous non-small-cell lung cancer (NSCLC) metastatic to the brain CA209-7WF / Break B5-BM-NSCLC
Active, not recruitingCTIS2024-512684-31-00
Universitaetsklinikum Regensburg AöRnon-squamous nonsmall-cell lung cancer (NSCLC) metastatic to the brain
Start: 2021-04-14Target: 39Updated: 2025-12-05
ETOP 18-21 AMAZE-lung: A multicentre single-arm phase II trial of amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI.
Active, not recruitingCTIS2024-512288-29-00
ETOP IBCSG Partners FoundationPatients with EGFR-mutant (L858R or del19 only) advanced non-squamous NSCLC, who have progressed on previous treatment with a third-generation EGFR-TKI.
Start: 2023-04-11Target: 30Updated: 2025-06-06
An Open-label, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of Induction Treatment with Melphalan/HDS Followed by Consolidation Treatment with Trifluridine–tipiracil plus Bevacizumab Versus Trifluridine–tipiracil plus Bevacizumab Alone in Patients with Refractory Metastatic Colorectal Cancer with Liver Dominant Disease
RecruitingCTIS2024-520356-24-00
Delcath Systems Inc.Refractory Metastatic Colorectal Cancer with Liver Dominant Disease
Start: 2025-12-01Target: 35Updated: 2025-11-21

Phase 3