Zileuton

DRUG14 trials

Sponsors

Barbara Ann Karmanos Cancer Institute, Alliance for Clinical Trials in Oncology, Critical Therapeutics, University of Michigan, National Human Genome Research Institute (NHGRI)

Conditions

Acne VulgarisAsthmaChronic Myelogenous LeukemiaHead and Neck CancerHermansky-Pudlak Syndrome (HPS)Idiopathic Pulmonary FibrosisLung CancerLung Inflammation

Early Phase 1

Evaluation of Rosiglitazone Anti-inflammatory Effect With FDG-PET Imaging

CompletedNCT01174056

Washington University School of MedicineLung Inflammation

Start: 2011-07-31End: 2014-03-31Updated: 2014-04-23

Phase 1

Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome

TerminatedNCT00467831

National Human Genome Research Institute (NHGRI)Hermansky-Pudlak Syndrome (HPS), Metabolic Disease, Oculocutaneous Albinism +2

Start: 2007-04-30End: 2012-11-30Updated: 2013-08-02

Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers

CompletedNCT01021215

National Cancer Institute (NCI)Tobacco Use Disorder

Start: 2010-05-31End: 2013-03-31Updated: 2015-04-02

Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML.

TerminatedNCT01130688

University of Massachusetts, WorcesterChronic Myelogenous Leukemia

Start: 2010-01-31End: 2014-12-31Updated: 2015-05-27

Trial of Zileuton CR in Children and Adults With Sickle Cell Disease

CompletedNCT01136941

Children's Hospital Medical Center, CincinnatiSickle Cell Disease

Start: 2010-09-30End: 2013-04-30Updated: 2014-06-18

Phase 2

Zileuton in Preventing Lung Cancer in Patients With Bronchial Dysplasia

CompletedNCT00056004

Barbara Ann Karmanos Cancer InstituteHead and Neck Cancer, Lung Cancer

Start: 2003-06-30End: 2009-03-31Updated: 2013-04-29

Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer

CompletedNCT00070486

Alliance for Clinical Trials in OncologyLung Cancer

Start: 2003-12-31End: 2011-05-31Updated: 2016-06-30

Study of Oral Zileuton in the Treatment of Moderate to Severe Facial Acne Vulgaris

Critical TherapeuticsAcne Vulgaris

Start: 2004-11-30End: 2005-05-31Target: 90Updated: 2007-02-07

Zileuton for the Treatment of Idiopathic Pulmonary Fibrosis

CompletedNCT00262405

University of MichiganIdiopathic Pulmonary Fibrosis

Start: 2001-01-31End: 2007-05-31Updated: 2015-12-03

Assessment of PFT, Safety, and PK of Zileuton Injection in Asthma Patients

CompletedNCT00534625

Critical TherapeuticsAsthma

Start: 2007-09-30End: 2008-03-31Updated: 2008-03-21

PF-04191834 Single Dose Bronchodilatory Study In Asthma.

CompletedNCT00723021

Start: 2008-07-31End: 2009-07-31Updated: 2013-02-01

Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers

CompletedNCT02348203

National Cancer Institute (NCI)Tobacco Use Disorder

Start: 2016-01-13End: 2021-03-09Updated: 2022-06-02

Phase 3

Zileuton to Treat Adults With Chronic Obstructive Pulmonary Disease (The LEUKO Study)

TerminatedNCT00493974

University of MinnesotaPulmonary Disease, Chronic Obstructive

Start: 2007-03-31End: 2008-12-31Updated: 2019-11-18

Phase 4

Zileuton and Exhaled Nitric Oxide in Asthmatics

CompletedNCT00575861

Gelb, Arthur F., M.D.Asthma

Start: 2005-09-30End: 2007-11-30Updated: 2007-12-20

Related Papers

Serum Soluble ST2 (sST2) is Associated With Chronic Obstructive Pulmonary Disease (COPD) Exacerbations and Enhanced Treatment Response to Astegolimab (Anti-ST2)

American Journal of Respiratory and Critical Care Medicine2025-05-01

The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study

PLoS ONE2018-02-079 citations

A Phase I Trial Of Zileuton In Sickle Cell Disease

Blood2013-11-159 citations