Zilebesiran
Sponsors
Alnylam Pharmaceuticals Inc., Alnylam Pharmaceuticals
Conditions
Established cardiovascular diseaseHigh Cardiovascular RiskHigh Risk Cardiovascular DiseaseHigh cardiovascular riskHypertensionMild to Moderate Hypertension
Phase 1
Phase 2
Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)
CompletedNCT05103332
Start: 2021-11-05End: 2024-09-13Updated: 2025-11-03
Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)
CompletedNCT06272487
Start: 2024-02-29End: 2025-12-01Updated: 2026-03-02
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran
RecruitingNCT07553442
Start: 2026-04-27End: 2028-10-01Target: 93Updated: 2026-09-14
Phase 3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
RecruitingNCT07181109
Start: 2025-09-22End: 2030-09-23Target: 11000Updated: 2026-09-18
ZENITH: A Phase 3 Global, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Zilebesiran in Addition to Standard of Care in Reducing Major Adverse Cardiovascular Events in Adult Patients with Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
Not yet recruitingCTIS2025-522960-34-00
Target: 1190Updated: 2026-02-04