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ZD6474

DRUG16 trials

Sponsors

Genzyme, a Sanofi Company, National Cancer Institute (NCI), M.D. Anderson Cancer Center, Dana-Farber Cancer Institute, Patrick Y. Wen, MD

Conditions

Biliary CancerBreast NeoplasmsCarcinoma, Non-Small-Cell LungColorectal CancerGlioblastoma MultiformeGliosarcomaLung CancerMalignant Gliomas

Phase 1

ZD6474 to Treat Advanced Brain Cancer in Patients
CompletedNCT00272350
National Cancer Institute (NCI)Malignant Gliomas, Progressive Low-Grade Gliomas, Recurrent High-Grade Gliomas
Start: 2005-12-29End: 2014-02-27Updated: 2019-12-05
ZD6474, Cetuximab, and Irinotecan in Patients With Metastatic Colorectal Cancer
CompletedNCT00436072
Dana-Farber Cancer InstituteColorectal Cancer
Start: 2007-02-28End: 2012-08-31Target: 46Updated: 2012-10-04
Zactima With Temodar During Radiation Treatment for Newly Diagnosed Stage IV Brain Tumors
CompletedNCT00441142
Patrick Y. Wen, MDGlioblastoma Multiforme, Gliosarcoma
Start: 2007-05-25End: 2017-10-10Updated: 2019-03-05
ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma
TerminatedNCT00533169
M.D. Anderson Cancer CenterNeuroblastoma
Start: 2007-09-30End: 2011-02-28Updated: 2011-12-15
Gemcitabine/Capecitabine/ZD6474 in Advanced Solid Tumors
CompletedNCT00551096
University of Colorado, DenverBiliary Cancer, Malignant Solid Tumour, Pancreatic Cancer
Start: 2007-10-31End: 2013-05-31Updated: 2013-12-25
Investigate the Maximum Tolerated Dose of Vandetanib and Concurrent Whole Brain Radiotherapy (WBRT) in Patients With Non-small Cell Lung Cancer (NSCLC) and Brain Metastases
TerminatedNCT00807170
SanofiNon-small Cell Lung Cancer (NSCLC)
Start: 2009-05-31End: 2010-08-31Updated: 2016-08-29

Phase 2

This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Metastatic Breast Cancer
CompletedNCT00034918
Genzyme, a Sanofi CompanyBreast Neoplasms, Metastases, Neoplasm
Start: 2002-05-31End: 2003-11-30Target: 44Updated: 2016-08-24
Efficacy Study of ZD6474 to Treat Multiple Myeloma Cancer
CompletedNCT00047788
Genzyme, a Sanofi CompanyMultiple Myeloma
Start: 2002-10-31End: 2004-05-31Target: 30Updated: 2016-08-24
This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Non-small Cell Lung Cancer.
CompletedNCT00047840
Genzyme, a Sanofi CompanyNon-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line
Start: 2002-10-31End: 2006-09-30Target: 129Updated: 2016-08-25
This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC.
CompletedNCT00059722
Genzyme, a Sanofi CompanyCarcinoma, Non-Small-Cell Lung
Start: 2003-05-31End: 2007-06-30Target: 160Updated: 2016-08-24
ZD6474 Alone or in Combination With Paclitaxel and Carboplatin in Subjects With Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)
CompletedNCT00071188
Genzyme, a Sanofi CompanyCarcinoma, Non-Small-Cell Lung
Start: 2004-02-29End: 2007-10-31Updated: 2016-08-25
Phase II Study of ZD6474 in Advanced NSCLC
TerminatedNCT00290537
M.D. Anderson Cancer CenterLung Cancer
Start: 2006-01-31End: 2008-04-30Updated: 2016-05-19
Malignant Pleural Effusion With ZD6474
TerminatedNCT00402896
M.D. Anderson Cancer CenterLung Cancer, Pleural Effusion
Start: 2006-10-31End: 2014-06-30Updated: 2016-03-09
BATTLE Program: ZD6474 in Previously Treated Subjects With NSCLC
CompletedNCT00410189
M.D. Anderson Cancer CenterLung Cancer
Start: 2006-11-30End: 2013-03-31Updated: 2015-03-23
Docetaxel in Combination With Zactima (ZD6474) in Patients With Locally Advanced Squamous Cell Carcinoma of the the Head and Neck
CompletedNCT00459043
Dana-Farber Cancer InstituteSquamous Cell Carcinoma of Head and Neck
Start: 2007-03-31End: 2012-02-29Updated: 2013-07-03
Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer
CompletedNCT00613626
Hoosier Cancer Research NetworkSmall Cell Lung Cancer
Start: 2008-01-31End: 2015-08-31Updated: 2020-02-11

Related Papers

Phase I trial of vandetanib in combination with gemcitabine and capecitabine in patients with advanced solid tumors with an expanded cohort in pancreatic and biliary cancers.
2015-12-3015 citations
A randomized double-blind phase II trial of platinum (P) plus etoposide (E) with or without concurrent ZD6474 (Z) in patients (pts) with previously untreated extensive-stage (ES) small cell lung cancer (SCLC): Hoosier Oncology Group LUN06-113.
Journal of Clinical Oncology2014-05-202 citations
The use of improved and complete enrichment co-amplification at lower denaturation temperature (ICE COLD-PCR) method for the detection of <i>EGFR</i> and <i>KRAS </i>mutations from cell-free plasma DNA of non-small cell lung cancer (NSCLC) patients.
Journal of Clinical Oncology2014-05-20
Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
2012-06-1234 citations