YESCARTA 0.4 – 2 x 10e8 cells dispersion for infusion
Sponsors
Kite Pharma Inc., Lymphoma Academic Research Organisation, Universitaet Muenster, Universitair Medisch Centrum Groningen, Centre Hospitalier Universitaire De Saint Etienne
Conditions
Diffuse large B-cell lymphoma) and aggressive B-cell lymphomas (HGBCLDiffuse large B-cell lymphomas (DLBCLFirst-line treatment of adult subjects with high-risk large B-cell lymphoma (LBCL) including diffuse large B-cell lymphomaFollicular LymphomaHigh-grade B-cell lymphoma) originate from mature B-cells at various stages of terminal differentiationIndolent Non-Hodgkin LymphomaMarginal Zone LymphomaNOS) and high-grade B-cell lymphoma (HGBL).
Phase 2
A PHASE 2 MULTICENTER STUDY OF AXICABTAGENE CILOLEUCEL IN SUBJECTS WITH RELAPSED/REFRACTORY INDOLENT NON-HODGKIN LYMPHOMA (INHL)
CompletedCTIS2023-505169-10-00
Start: 2018-09-07End: 2024-10-03Target: 10Updated: 2024-04-08
Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells
RecruitingCTIS2023-507041-28-00
Start: 2022-11-28Target: 96Updated: 2025-09-23
CARMOD - Golcadomide (BMS-986369) post-CAR T-cell in R/R Aggressive large B-cell lymphoma patients with high risk of relapse
RecruitingCTIS2023-506705-20-00
Start: 2024-06-14Target: 61Updated: 2024-05-28
HOVON 161: A phase II non-inferiority study comparing point-of-care produced CAR T-cell to commercial CAR T-cells in patients with relapsed/refractory Non-Hodgkin Lymphoma
RecruitingCTIS2024-511979-15-00
Start: 2022-10-14Target: 340Updated: 2025-05-22
A phase II efficacy and safety study of cell-free circulating tumor DNA-guided commencement of second-line treatment in patients with DLBCL/HGBCL relapse
Not yet recruitingCTIS2024-518275-64-00
Target: 340Updated: 2025-11-24
Axicabtagene Ciloleucel CAR T-Cells in Patients with relapsed or refractory primary mediastinal B-Cell Lymphoma
CompletedCTIS2024-510972-19-00
Start: 2025-03-13End: 2025-07-25Target: 40Updated: 2025-06-16
Phase 3
An Adaptive Phase 3, Randomized, Open-Label, Multicenter Study to Compare the Efficacy and Safety of Axicabtagene Ciloleucel versus Standard of Care Therapy as First-Line Therapy in Subjects with High-Risk Large B-Cell Lymphoma (ZUMA-23)
Active, not recruitingCTIS2022-501489-24-00
Start: 2025-03-28Target: 127Updated: 2026-01-21
A Phase 3 Randomized, Open-Label, Multicenter Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects with Relapsed/Refractory Follicular Lymphoma
Active, not recruitingCTIS2024-511594-30-00
Start: 2023-02-23Target: 142Updated: 2026-01-14
Phase 4
Temporal characterization of Extracellular Vesicles during cellular therapy using CAR-T cells and during the occurrence of Immune effector Cell-Associated Neurotoxicity Syndrome : the VESICANS study
RecruitingCTIS2024-515328-35-00
Start: 2025-07-02Target: 60Updated: 2025-04-17
Fludarabine exposure in patients undergoing Fludarabine based lymphodepletion prior to CAR-T cell therapy
Not yet recruitingCTIS2025-524278-40-00
Target: 75Updated: 2026-03-23