Xyrem

DRUG5 trials

Sponsors

Jazz Pharmaceuticals, State University of New York - Upstate Medical University, Centre for Addiction and Mental Health

Conditions

Anxiety, Post TraumaticHealthy ControlsNarcolepsyNarcolepsy With CataplexyPTSDcataplexy narcolepsy

Phase 2

Xyrem for Treatment Refractory Insomnia Due to PTSD

WithdrawnNCT00330291

State University of New York - Upstate Medical UniversityAnxiety, Post Traumatic, PTSD

Start: 2005-08-31End: 2006-08-31Updated: 2012-09-07

Phase 3

Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy

CompletedNCT00066170

Jazz PharmaceuticalsNarcolepsy

Start: 2003-04-30End: 2004-11-30Updated: 2011-12-29

A Multicenter Study of the Efficacy and Safety of Xyrem With an Open- Label Pharmacokinetic Evaluation and Safety Extension in Pediatric Subjects With Narcolepsy With Cataplexy

CompletedNCT02221869

Jazz PharmaceuticalsNarcolepsy With Cataplexy

Start: 2014-10-01End: 2019-01-25Updated: 2019-04-30

Phase 4

Xyrem and Brain Dopamine in Narcolepsy

CompletedNCT02637076

Centre for Addiction and Mental HealthHealthy Controls, Narcolepsy With Cataplexy

Start: 2016-01-31End: 2020-01-23Updated: 2021-03-23

Unknown Phase

An open-label, randomized, crossover study to evaluate the pharmacokinetics, bioavailability, and bioequivalence following administration of JZP-507 oral solution and Xyrem®in healthy subjects.

Jazz Pharmaceuticalscataplexy narcolepsy

Target: 60Updated: 2024-02-28

Related Papers

Effect of sodium oxybate on body mass index in pediatric patients with narcolepsy.

2024-03-014 citations

Long-term safety and maintenance of efficacy of sodium oxybate in the treatment of narcolepsy with cataplexy in pediatric patients.

2022-09-0110 citations

Validation of the Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD) questionnaire in pediatric patients with narcolepsy with cataplexy aged 7-16 years.

2021-11-1112 citations

Incidence and duration of common, early-onset adverse events occurring during 2 randomized, placebo-controlled, phase 3 studies of sodium oxybate in participants with narcolepsy

Journal of Clinical Sleep Medicine2020-05-018 citations

Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation.

2018-05-2163 citations

Effect of sodium oxybate, modafinil, and their combination on disrupted nighttime sleep in narcolepsy

Sleep Medicine2017-10-1233 citations