Xtandi - 40 mg soft capsules
Sponsors
Bayer Consumer Care AG, Bayer AG, AstraZeneca AB, Pfizer Inc., Essa Pharma Inc., European Organisation For Research And Treatment Of Cancer
Conditions
Castration resistant prostate cancer patients metastatic to bone.Localised prostate cancer at high risk of recurrenceMETASTATIC CASTRATION RESISTANT PROSTATE CANCERMETASTATIC CASTRATION-SENSITIVE PROSTATE CANCERMetastatic Castration-resistant Prostate CancerMetastatic Castration-sensitive Prostate CancerMetastatic Prostate CancerMetastatic castration-resistant prostate cancer
Phase 1
A Multi-arm, Open-label Phase I/IIa Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of AZD5305 in Combination with New Hormonal Agents in Patients with Metastatic Prostate Cancer (PETRANHA)
Active, not recruitingCTIS2023-508536-64-00
Start: 2022-05-17Target: 50Updated: 2025-04-28
A Phase 1/2 Study of EPI-7386 in Combination with Enzalutamide Compared with Enzalutamide Alone in Subjects with Metastatic Castration-Resistant Prostate Cancer
CompletedCTIS2023-509336-25-00
Start: 2024-06-12End: 2024-10-31Target: 50Updated: 2024-10-01
Phase 3
C3441052 - TALAPRO-3: A Phase 3, Randomized, Double-Blind Study of Talazoparib with Enzalutamide Versus Placebo with Enzalutamide in Men with DDR Gene Mutated Metastatic Castration-Sensitive Prostate Cancer
Active, not recruitingCTIS2024-510809-28-00
Start: 2021-09-27Target: 207Updated: 2025-12-19
EORTC 1333-GU: A Randomized multicenter phase III trial comparing enzalutamide vs. a combination of Ra223 and enzalutamide in asymptomatic or mildly symptomatic castration resistant prostate cancer patients metastatic to bone (PEACE III)
Active, not recruitingCTIS2023-510453-41-00
Start: 2015-10-26Target: 255Updated: 2024-08-23
C3431004/MDV3100-13: A Phase 3, Randomized, Efficacy and Safety Study of Enzalutamide Plus Leuprolide, Enzalutamide Monotherapy, and Placebo Plus Leuprolide in Men With High-Risk Nonmetastatic Prostate Cancer Progressing After Definitive Therapy.
Active, not recruitingCTIS2024-513521-23-00
Start: 2015-08-19Target: 366Updated: 2025-12-12
Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer: ENZARAD
CompletedCTIS2024-514808-13-00
Start: 2015-03-06End: 2025-10-03Target: 79Updated: 2026-01-23
Randomised phase 3 trial of enzalutamide in first line androgen deprivation therapy for metastatic prostate cancer: ENZAMET
Active, not recruitingCTIS2024-516137-13-00
Start: 2014-12-18Target: 82Updated: 2025-08-05
C3441021 - TALAPRO 2: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER.
Active, not recruitingCTIS2023-509087-20-00
Start: 2019-04-16Target: 411Updated: 2025-12-16
C2321014: A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF PF-06821497 (MEVROMETOSTAT) IN COMBINATION WITH ENZALUTAMIDE COMPARED WITH ENZALUTAMIDE OR DOCETAXEL IN PARTICIPANTS WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER PREVIOUSLY TREATED WITH ABIRATERONE ACETATE (MEVPRO-1)
RecruitingCTIS2024-511650-50-00
Start: 2025-01-17Target: 205Updated: 2025-12-09
C2321008: A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER (MEVPRO-3)
Not yet recruitingCTIS2024-519369-24-00
Target: 434Updated: 2026-01-12
Phase 4
(20510) A Phase 4, randomized, open-label, multicenter efficacy and safety study of standard dose of radium-223 dichloride vs. standard doses of novel anti-hormonal therapy (NAH) in patients with bone dominant metastatic castration resistant prostate cancer (mCRPC) progressing on/after one line of NAH
Active, not recruitingCTIS2023-505830-89-00
Start: 2020-08-05Target: 514Updated: 2025-10-07
Translational research study to discover molecular changes in patients with localized prostate cancer undergoing robotic-assisted radical prostatectomy and treated for 4 weeks with Enzalutamide compared to those not treated with Enzalutamide
RecruitingCTIS2024-514786-19-01
Start: 2025-01-27Target: 30Updated: 2025-01-08