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Xtandi - 40 mg soft capsules

DRUG12 trials

Sponsors

Bayer Consumer Care AG, Bayer AG, AstraZeneca AB, Pfizer Inc., Essa Pharma Inc., European Organisation For Research And Treatment Of Cancer

Conditions

Castration resistant prostate cancer patients metastatic to bone.Localised prostate cancer at high risk of recurrenceMETASTATIC CASTRATION RESISTANT PROSTATE CANCERMETASTATIC CASTRATION-SENSITIVE PROSTATE CANCERMetastatic Castration-resistant Prostate CancerMetastatic Castration-sensitive Prostate CancerMetastatic Prostate CancerMetastatic castration-resistant prostate cancer

Phase 1

Phase 3

C3441052 - TALAPRO-3: A Phase 3, Randomized, Double-Blind Study of Talazoparib with Enzalutamide Versus Placebo with Enzalutamide in Men with DDR Gene Mutated Metastatic Castration-Sensitive Prostate Cancer
Active, not recruitingCTIS2024-510809-28-00
Pfizer Inc.Metastatic Castration-sensitive Prostate Cancer
Start: 2021-09-27Target: 207Updated: 2025-12-19
EORTC 1333-GU: A Randomized multicenter phase III trial comparing enzalutamide vs. a combination of Ra223 and enzalutamide in asymptomatic or mildly symptomatic castration resistant prostate cancer patients metastatic to bone (PEACE III)
Active, not recruitingCTIS2023-510453-41-00
European Organisation For Research And Treatment Of CancerCastration resistant prostate cancer patients metastatic to bone.
Start: 2015-10-26Target: 255Updated: 2024-08-23
C3431004/MDV3100-13: A Phase 3, Randomized, Efficacy and Safety Study of Enzalutamide Plus Leuprolide, Enzalutamide Monotherapy, and Placebo Plus Leuprolide in Men With High-Risk Nonmetastatic Prostate Cancer Progressing After Definitive Therapy.
Active, not recruitingCTIS2024-513521-23-00
Medivation Inc.Prostate Cancer
Start: 2015-08-19Target: 366Updated: 2025-12-12
Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer: ENZARAD
CompletedCTIS2024-514808-13-00
Cancer Trials IrelandLocalised prostate cancer at high risk of recurrence
Start: 2015-03-06End: 2025-10-03Target: 79Updated: 2026-01-23
Randomised phase 3 trial of enzalutamide in first line androgen deprivation therapy for metastatic prostate cancer: ENZAMET
Active, not recruitingCTIS2024-516137-13-00
Cancer Trials IrelandMetastatic Prostate Cancer
Start: 2014-12-18Target: 82Updated: 2025-08-05
C3441021 - TALAPRO 2: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER.
Active, not recruitingCTIS2023-509087-20-00
Pfizer Inc.Metastatic Castration-resistant Prostate Cancer
Start: 2019-04-16Target: 411Updated: 2025-12-16
C2321014: A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF PF-06821497 (MEVROMETOSTAT) IN COMBINATION WITH ENZALUTAMIDE COMPARED WITH ENZALUTAMIDE OR DOCETAXEL IN PARTICIPANTS WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER PREVIOUSLY TREATED WITH ABIRATERONE ACETATE (MEVPRO-1)
RecruitingCTIS2024-511650-50-00
Pfizer Inc.METASTATIC CASTRATION RESISTANT PROSTATE CANCER
Start: 2025-01-17Target: 205Updated: 2025-12-09
C2321008: A PHASE 3, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER (MEVPRO-3)
Not yet recruitingCTIS2024-519369-24-00
Pfizer Inc.METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER
Target: 434Updated: 2026-01-12

Phase 4