XPF-010
Sponsors
Xenon Pharmaceuticals Inc.
Conditions
Adult focal (partial onset) epilepsyDepressive episodes associated with Bipolar disorder I or II (Bipolar Depression)Focal Onset SeizuresFocal-onset SeizuresHealthy VolunteersPrimary Generalized Tonic-Clonic SeizuresPrimary generalized tonic-clonic seizures
Phase 1
Phase 2
Phase 3
A Randomized, Double-blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures
CompletedCTIS2022-502000-73-00
Start: 2023-08-11End: 2026-01-09Target: 168Updated: 2025-09-30
A Randomized, Double-blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures
RecruitingCTIS2022-502281-25-00
Start: 2023-09-27Target: 197Updated: 2026-01-12
A Randomized, Double-blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures (X-ACKT)
RecruitingCTIS2022-502286-16-00
Start: 2023-10-27Target: 106Updated: 2025-10-24
A Multicenter, Open-label, Long-term, Safety, Tolerability, and Efficacy Study of XEN1101 in Subjects Diagnosed With Epilepsy (X-TOLE4)
RecruitingCTIS2022-502282-24-00
Start: 2024-02-14Target: 446Updated: 2025-11-17
A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Azetukalner in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
Not yet recruitingCTIS2025-522775-29-00
Target: 21Updated: 2026-03-10
A Multicenter, Long-term, Open-Label, Safety, Tolerability, and Efficacy Study of Azetukalner in Bipolar I or II Depression
Not yet recruitingCTIS2025-522872-10-00
Target: 20Updated: 2026-04-29