XL092
Sponsors
Exelixis Inc., Merck Sharp & Dohme LLC, Hoffmann-La Roche, Exelixis, University of Utah
Conditions
Advanced Renal Cell CarcinomaAdvanced or Metastatic Non-Clear Cell Renal Cell CarcinomaAnaplastic Thyroid CancerBRAF Mutation-Related TumorsCarcinoma, Non-Small-Cell LungClear Cell Renal Cell CarcinomaClear cell renal cell carcinomaClear cell renal cell carcinoma (ccRCC
Phase 1
A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)
CompletedNCT03337698
Start: 2017-12-27End: 2025-11-25Updated: 2025-12-12
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
Active, not recruitingNCT03845166
Start: 2019-03-20End: 2027-05-31Updated: 2024-11-19
A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination with Immuno-Oncology Agents in Subjects with Unresectable Advanced or Metastatic Solid Tumors
Active, not recruitingCTIS2023-510061-10-00
Start: 2023-01-09Target: 407Updated: 2025-11-06
XL092 and Cemiplimab in BRAF WT Thyroid Cancer
RecruitingNCT06902376
Start: 2025-06-03End: 2028-08-31Target: 12Updated: 2025-11-05
A Phase 1b/2 Study of Immune and Targeted Combination Therapies in Participants with RCC (KEYMAKER-U03): Substudy 03C in Participants With Recurrent Disease During or After Anti-PD-(L)1 Adjuvant Therapy
RecruitingCTIS2024-516437-12-00
Start: 2025-08-29Target: 33Updated: 2026-01-19
Phase 2
XL092 in Patients With Metastatic Castration-Resistant Prostate Cancer
RecruitingNCT06568562
Start: 2024-12-09End: 2028-12-31Target: 32Updated: 2025-12-09
Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC
RecruitingNCT06863311
Start: 2026-03-13End: 2028-12-31Target: 70Updated: 2026-04-03
A Phase 2/3, multicenter, randomized open-label study of zanzalintinib vs everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors
Not yet recruitingCTIS2025-521043-20-00
Target: 172Updated: 2026-01-14
H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)
Not yet recruitingNCT07484139
Start: 2026-05-01End: 2028-05-01Target: 26Updated: 2026-03-20
Phase 3
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
Active, not recruitingNCT05425940
Start: 2022-09-07End: 2027-01-31Updated: 2025-10-23
Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
Active, not recruitingNCT05678673
Start: 2023-01-01End: 2028-06-30Updated: 2025-07-14
A Randomized Open-Label Phase 3 Study of XL092 + Nivolumab vs Sunitinib in Subjects with Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
RecruitingCTIS2022-501703-27-00
Start: 2023-07-05Target: 196Updated: 2025-12-02
A Randomized Open-Label Phase 3 Study of XL092 + Atezolizumab vs Regorafenib in Subjects with Metastatic Colorectal Cancer
Active, not recruitingCTIS2024-512915-33-00
Start: 2022-12-22Target: 328Updated: 2026-01-04
A Phase 3, Randomized, Open-label Study of Belzutifan + Zanzalintinib Versus Cabozantinib in Participants with Advanced RCC who Experienced Disease Recurrence During or After Prior Adjuvant Anti-PD-1/L1 Therapy (LITESPARK-033)
RecruitingCTIS2024-517136-21-00
Start: 2025-12-05Target: 398Updated: 2025-11-17
Related Papers
5 more papers not shown