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XL092

DRUG14 trials

Sponsors

Exelixis Inc., Merck Sharp & Dohme LLC, Hoffmann-La Roche, Exelixis, University of Utah

Conditions

Advanced Renal Cell CarcinomaAdvanced or Metastatic Non-Clear Cell Renal Cell CarcinomaAnaplastic Thyroid CancerBRAF Mutation-Related TumorsCarcinoma, Non-Small-Cell LungClear Cell Renal Cell CarcinomaClear cell renal cell carcinomaClear cell renal cell carcinoma (ccRCC

Phase 1

A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)
CompletedNCT03337698
Hoffmann-La RocheCarcinoma, Non-Small-Cell Lung
Start: 2017-12-27End: 2025-11-25Updated: 2025-12-12
A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
Active, not recruitingNCT03845166
ExelixisColorectal Cancer, Hormone Receptor Positive Breast Carcinoma, Metastatic Castration-resistant Prostate Cancer +2
Start: 2019-03-20End: 2027-05-31Updated: 2024-11-19
A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination with Immuno-Oncology Agents in Subjects with Unresectable Advanced or Metastatic Solid Tumors
Active, not recruitingCTIS2023-510061-10-00
Exelixis Inc.Clear cell renal cell carcinoma (ccRCC, first-, first-line) cell carcinoma - Colorectal cancer (CRC) - Hepatocellular cancer (HCC) - Non-small cell lung caner (NSCLC) - Head and Neck Squamous Cell Carcinoma (HNSCC) +2
Start: 2023-01-09Target: 407Updated: 2025-11-06
XL092 and Cemiplimab in BRAF WT Thyroid Cancer
RecruitingNCT06902376
UNC Lineberger Comprehensive Cancer CenterAnaplastic Thyroid Cancer, BRAF Mutation-Related Tumors, Thyroid Cancer
Start: 2025-06-03End: 2028-08-31Target: 12Updated: 2025-11-05
A Phase 1b/2 Study of Immune and Targeted Combination Therapies in Participants with RCC (KEYMAKER-U03): Substudy 03C in Participants With Recurrent Disease During or After Anti-PD-(L)1 Adjuvant Therapy
RecruitingCTIS2024-516437-12-00
Merck Sharp & Dohme LLCClear cell renal cell carcinoma
Start: 2025-08-29Target: 33Updated: 2026-01-19

Phase 2

Phase 3

Related Papers

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