Xanomeline Enteric Capsule

DRUG3 trials

Sponsors

Bristol-Myers Squibb

Conditions

Alzheimer DiseaseHealthy Volunteers

Phase 1

A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, and to Explore the Effect of Food After Multiple Doses of Selected Prototypes in Healthy Adult Participants

RecruitingNCT07063342

Bristol-Myers SquibbHealthy Volunteers

Start: 2025-06-27End: 2026-08-15Target: 72Updated: 2025-12-19

Phase 3

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

RecruitingNCT07011732

Bristol-Myers SquibbAlzheimer Disease

Start: 2025-07-10End: 2028-12-08Target: 352Updated: 2026-04-01

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-2)

RecruitingNCT07011745

Bristol-Myers SquibbAlzheimer Disease

Start: 2025-07-16End: 2028-11-13Target: 352Updated: 2026-04-01