Xanomeline Enteric Capsule

DRUG3 trials

Sponsors

Bristol-Myers Squibb

Conditions

Alzheimer DiseaseAlzheimer's DiseaseHealthy Volunteers

Phase 1

A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, Explore the Effect of Food After Multiple Doses of Selected Prototypes, and Evaluate Alternative Formulations of KarX and KarXT Following Single and Multiple Ascending Doses

RecruitingNCT07063342

Bristol-Myers SquibbHealthy Volunteers

Start: 2025-06-27End: 2027-03-29Target: 236Updated: 2026-08-17

Phase 3

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

RecruitingNCT07011732

Bristol-Myers SquibbAlzheimer Disease

Start: 2025-07-10End: 2028-12-08Target: 426Updated: 2026-08-11

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease

RecruitingNCT07011745

Bristol-Myers SquibbAlzheimer's Disease

Start: 2025-07-16End: 2028-11-13Target: 426Updated: 2026-08-26