Whole-Brain Radiotherapy

RADIATION14 trials

Sponsors

National Cancer Institute (NCI), M.D. Anderson Cancer Center, British Columbia Cancer Agency, Instituto Nacional de Cancerologia de Mexico, NRG Oncology

Conditions

Adult Solid NeoplasmAnatomic Stage IV Breast Cancer AJCC v8Brain MetastasesCarcinoma, Non-Small-Cell LungExtensive Stage Lung Small Cell CarcinomaHER2-Positive Breast CarcinomaHER2/Neu NegativeHER2/Neu Positive

Early Phase 1

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

RecruitingNCT06328686

Emory UniversityMetastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm

Start: 2024-09-05End: 2027-12-31Target: 10Updated: 2025-09-17

Phase 1

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

TerminatedNCT01217411

National Cancer Institute (NCI)Adult Solid Neoplasm, Extensive Stage Lung Small Cell Carcinoma, HER2/Neu Negative +10

Start: 2010-10-01End: 2011-11-30Updated: 2024-11-19

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Active, not recruitingNCT02015117

National Cancer Institute (NCI)Metastatic Malignant Neoplasm in the Brain

Start: 2014-04-28End: 2026-10-08Updated: 2026-04-03

Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors

Active, not recruitingNCT02589522

National Cancer Institute (NCI)Metastatic Lung Neuroendocrine Neoplasm, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Lung Small Cell Carcinoma +4

Start: 2017-05-22End: 2026-09-18Updated: 2025-10-08

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

Active, not recruitingNCT02696993

M.D. Anderson Cancer CenterMetastatic Malignant Neoplasm in the Brain, Stage IV Non-Small Cell Lung Cancer AJCC v7

Start: 2016-12-16End: 2027-12-31Updated: 2025-11-07

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Active, not recruitingNCT02993146

National Cancer Institute (NCI)Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Brain

Start: 2017-05-08End: 2026-10-03Updated: 2025-10-29

Phase 2

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

CompletedNCT01622868

National Cancer Institute (NCI)HER2-Positive Breast Carcinoma, Invasive Breast Carcinoma, Metastatic Malignant Neoplasm in the Brain +2

Start: 2012-12-06End: 2022-05-20Updated: 2023-10-17

Nitroglycerin Plus Intracranial Radiotherapy for Brain Metastases in NSCLC Patients

CompletedNCT04338867

Instituto Nacional de Cancerologia de MexicoICPFS Evaluated by Two Blinded and Independent Radio-oncologist With MRI, Ninety-six Histologically Confirmed NSCLC Patients With BM, Phase II Clinical Trial +1

Start: 2020-03-01End: 2020-03-01Updated: 2020-04-22

Phase 3

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

Active, not recruitingNCT01592968

M.D. Anderson Cancer CenterMetastatic Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain

Start: 2012-08-02End: 2027-09-30Updated: 2026-03-09

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

TerminatedNCT04588246

NRG OncologyAnatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Lung Small Cell Carcinoma +9

Start: 2021-08-05End: 2024-08-06Updated: 2025-06-06

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

RecruitingNCT04804644

NRG OncologyMetastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Recurrent Lung Small Cell Carcinoma +1

Start: 2021-06-10End: 2030-07-01Target: 200Updated: 2026-04-03

Anlotinib Plus Whole-Brain Radiotherapy for Brain Metastases in SCLC Patients.

RecruitingNCT07443397

Cancer Institute and Hospital, Chinese Academy of Medical SciencesWhole-Brain Radiotherapy

Start: 2025-08-29End: 2027-12-31Target: 134Updated: 2026-03-02

Unknown Phase

Whole Brain Radiotherapy Versus Volumetric Modulated Arc Therapy for Brain Metastases

CompletedNCT02220491

British Columbia Cancer AgencyBrain Metastases

Start: 2014-10-01End: 2020-05-18Updated: 2020-05-20

Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis

Xiaorong DongBrain Metastases, Carcinoma, Non-Small-Cell Lung

Start: 2023-02-13End: 2024-10-01Target: 50Updated: 2023-02-21

Related Papers

Nitroglycerin Plus Whole Intracranial Radiation Therapy for Brain Metastases in Patients With Non-Small Cell Lung Cancer: A Randomized, Open-Label, Phase 2 Clinical Trial.

2022-02-127 citations

Whole Brain Irradiation or Stereotactic RadioSurgery for five or more brain metastases (WHOBI-STER): A prospective comparative study of neurocognitive outcomes, level of autonomy in daily activities and quality of life

Clinical and Translational Radiation Oncology2021-12-0231 citations

ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non–Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts

Molecular Cancer Therapeutics2021-08-1940 citations

Nitroglycerin (NTG) plus whole intracranial radiotherapy for brain metastases (BM) in non-small cell cancer patient (NSCLC): A randomized open label, phase II clinical trial.

Journal of Clinical Oncology2021-05-20

A Dutch phase III randomized multicenter trial: whole brain radiotherapy versus stereotactic radiotherapy for 4–10 brain metastases

Neuro-Oncology Advances2021-01-0136 citations

Concurrent nivolumab and ipilimumab with brain stereotactic radiosurgery for brain metastases from non-small cell lung cancer: A phase I trial.

Journal of Clinical Oncology2020-05-2011 citations

Whole Brain Radiotherapy Versus Stereotactic Radiosurgery in Poor-Prognosis Patients with One to 10 Brain Metastases: A Randomised Feasibility Study.

2020-02-199 citations

CMET-31. WHOLE BRAIN RADIOTHERAPY VERSUS STEREOTACTIC RADIOSURGERY IN POOR-PROGNOSIS PATIENTS WITH 1 – 10 BRAIN METASTASES: A RANDOMIZED FEASIBILITY STUDY

Neuro-Oncology2019-11-01

Abstract OT1-04-02: NRG oncology/RTOG 1119: Phase II randomized study of whole brain radiotherapy with concurrent lapatinib in patients with brain met from HER2-positive breast cancer — A collaborative study of RTOG & KROG (NCT01622868)

Cancer Research2017-02-153 citations

Abstract OT3-01-08: NRG oncology/RTOG 1119: Phase II randomized study of whole brain radiotherapy with concurrent lapatinib in patients with brain met from HER2-positive breast cancer — A collaborative study of RTOG and KROG (NCT01622868)

Cancer Research2016-02-15

RTOG 1119: Phase II randomized study of whole brain radiotherapy with concurrent lapatinib in patients with brain metastasis from HER2-positive breast cancer—A collaborative study of RTOG and KROG (NCT01622868).

Journal of Clinical Oncology2014-05-202 citations