FindTrial
Sign In

WEE1 Inhibitor AZD1775

DRUG4 trials

Sponsors

National Cancer Institute (NCI), University of Washington, Mayo Clinic

Conditions

CNS 2aCNS 2bCNS 2cCNS1Chronic Myelomonocytic LeukemiaHead and Neck Squamous Cell CarcinomaMyelodysplastic Syndrome With Isolated Del(5q)Myelodysplastic/Myeloproliferative Neoplasm

Phase 1

WEE1 Inhibitor MK-1775, Docetaxel, and Cisplatin Before Surgery in Treating Patients With Borderline Resectable Stage III-IVB Squamous Cell Carcinoma of the Head and Neck
CompletedNCT02508246
University of WashingtonHead and Neck Squamous Cell Carcinoma
Start: 2015-07-22End: 2018-04-26Updated: 2019-03-13
Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia
WithdrawnNCT02791919
National Cancer Institute (NCI)CNS1, CNS 2a, CNS 2b +3
Start: 2017-05-25End: 2019-05-31Updated: 2017-05-03

Phase 2

Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
TerminatedNCT02196168
National Cancer Institute (NCI)Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Laryngeal Verrucous Carcinoma +26
Start: 2014-03-31End: 2016-04-30Updated: 2017-05-03
WEE1 Inhibitor AZD1775 With or Without Cytarabine in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome
CompletedNCT02666950
Mayo ClinicChronic Myelomonocytic Leukemia, Myelodysplastic/Myeloproliferative Neoplasm, Myelodysplastic Syndrome With Isolated Del(5q) +3
Start: 2017-05-05End: 2018-10-17Updated: 2019-09-06

Related Papers

Phase I trial of WEE1 inhibition with chemotherapy and radiotherapy as adjuvant treatment, and a window of opportunity trial with cisplatin in patients with head and neck cancer: the <b>WISTERIA</b> trial protocol
BMJ Open2020-03-0137 citations
A phase I clinical trial of AZD1775 in combination with neoadjuvant weekly cisplatin and docetaxel in borderline resectable head and neck squamous cell carcinoma (HNSCC).
Journal of Clinical Oncology2017-05-202 citations