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WBRT

RADIATION13 trials

Sponsors

Pharmacyclics LLC., Alliance for Clinical Trials in Oncology, Baylor Breast Care Center, Hoffmann-La Roche, Melanoma and Skin Cancer Trials Limited

Conditions

Bladder CancerBrain MetastasesBreast CancerEGFR Gene MutationImmunotherapyLung CancerMetastatic CancerMetastatic Melanoma

Phase 2

Combination Chemotherapy With or Without Filgrastim in Treating Patients With Previously Untreated Extensive-Stage Small Cell Lung Cancer
CompletedNCT00028925
Alliance for Clinical Trials in OncologyLung Cancer
Start: 2001-11-30End: 2008-08-31Updated: 2016-12-07
Brain Mets - Capecitabine Plus Sunitinib and WBRT
TerminatedNCT00570908
Baylor Breast Care CenterBreast Cancer
Start: 2009-02-28End: 2013-09-30Updated: 2014-09-18
A Study of Whole Brain Radiation Therapy and Capecitabine in Breast Cancer Participants With Newly Diagnosed Brain Metastasis
TerminatedNCT00977379
Hoffmann-La RocheBreast Cancer
Start: 2009-08-31End: 2011-02-28Updated: 2016-11-15
Comparator-Controlled Study for EGFR(+) Patients With Multiple BMs From NSCLC (BROKE) (EGFR-epidermal Growth Factor Receptor;BM-brain Metastases)
NCT02338011
Shanghai Chest HospitalBrain Metastases, EGFR Gene Mutation, Non-Small Cell Lung Cancer
Start: 2014-11-30End: 2017-11-30Target: 210Updated: 2015-01-26
Study of Tumour Focused Radiotherapy for Bladder Cancer
Active, not recruitingNCT02447549
Institute of Cancer Research, United KingdomBladder Cancer
Start: 2015-10-21End: 2029-03-31Updated: 2020-06-09
IMRT Combined With Erlotinib for EGFR Wild Type Non-small Cell Lung Cancer With 4-10 Brain Metastases
TerminatedNCT02556593
Sun Yat-sen UniversityNon-Small Cell Lung Carcinoma
Start: 2015-09-30End: 2019-04-30Updated: 2019-04-12
Camrelizumab Combined With Local Treatment in NSCLC Patients With BM
NCT04291092
Zhejiang Cancer HospitalBrain Metastases, Immunotherapy, NSCLC Stage IV
Start: 2020-01-01End: 2023-06-30Target: 63Updated: 2021-09-10

Phase 3

Radiosurgery With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
CompletedNCT00030628
Alliance for Clinical Trials in OncologyMetastatic Cancer
Start: 2001-12-31End: 2014-10-31Updated: 2016-07-07
Radiation Therapy Plus Gadolinium Texaphyrin in Treating Patients With Brain Metastases
CompletedNCT00003563
Pharmacyclics LLC.Metastatic Cancer
Start: 1998-08-31End: 2005-06-30Target: 430Updated: 2013-10-31
Phase Ⅲ Trial of WBRT Versus Erlotinib Concurrent Whole-brain Radiation Therapy as first-line Treatment for Patients With Multiple Brain Metastases From Non-small-cell Lung Cancer(ENTER): a Multicentre, Open-label, Randomised Study
CompletedNCT01887795
Daping Hospital and the Research Institute of Surgery of the Third Military Medical UniversityMultiple Brain Metastases, Non-small-cell Lung Cancer
Start: 2013-08-31End: 2016-08-31Updated: 2016-08-25
Hypofractionated Brain Radiation In EGFR Mutated Adenocarcinoma Cranial Disease (Hybrid)
NCT02882984
Sichuan Provincial People's HospitalStage IV EGFR Mutated NSCL With Brain Metastases
Start: 2015-03-31End: 2020-12-31Target: 325Updated: 2016-08-30

Unknown Phase

Whole Brain Radiotherapy Following Local Treatment of Intracranial Metastases of Melanoma
NCT01503827
Melanoma and Skin Cancer Trials LimitedMetastatic Melanoma
Start: 2007-10-31End: 2022-06-30Target: 220Updated: 2021-01-07
Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases
CompletedNCT03297788
Juergen DebusBrain Metastases, SCLC
Start: 2017-12-01End: 2023-12-01Updated: 2024-01-05

Related Papers

Brain radiotherapy combined with camrelizumab and platinum-doublet chemotherapy for previously untreated advanced non-small-cell lung cancer with brain metastases (C-Brain): a multicentre, single-arm, phase 2 trial.
2025-01-0111 citations
Health-related quality of life analysis from ENTER, a randomized, controlled phase III trial of whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases
Translational Lung Cancer Research2024-12-011 citations
Bladder Tumor-Focused Adaptive Radiation Therapy: Clinical Outcomes of a Phase I Dose Escalation Study
International Journal of Radiation Oncology*Biology*Physics2024-07-273 citations
Stereotactic radiotherapy vs whole brain radiation therapy in EGFR mutated NSCLC: Results & reflections from the prematurely closed phase III HYBRID trial.
2024-05-255 citations
Longitudinal trajectory of quality of life for patients with melanoma brain metastases: A secondary analysis from a whole brain radiotherapy randomized clinical trial
Clinical and Translational Radiation Oncology2023-02-152 citations
A Dutch phase III randomized multicenter trial: whole brain radiotherapy versus stereotactic radiotherapy for 4–10 brain metastases
Neuro-Oncology Advances2021-01-0136 citations
Whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases: a multicenter, open-label, randomized, controlled phase III trial
Neuro-Oncology2020-12-1527 citations
Protocol for tumour-focused dose-escalated adaptive radiotherapy for the radical treatment of bladder cancer in a multicentre phase II randomised controlled trial (RAIDER): radiotherapy planning and delivery guidance
BMJ Open2020-12-0134 citations
Whole brain radiotherapy (WBRT) after local treatment of brain metastases in melanoma patients: Statistical Analysis Plan.
2019-08-055 citations
Dose-escalation of radiation may improve outcomes of squamous cell carcinoma of bladder
Clinical and Translational Radiation Oncology2019-07-24
Phase 3 international trial of adjuvant whole brain radiotherapy (WBRT) or observation (Obs) following local treatment of 1-3 melanoma brain metastases (MBMs).
Journal of Clinical Oncology2019-05-206 citations
Quality assurance analysis of hippocampal avoidance in a melanoma whole brain radiotherapy randomized trial shows good compliance.
2018-07-205 citations
Whole brain radiation therapy alone versus radiosurgery for patients with 1–10 brain metastases from small cell lung cancer (ENCEPHALON Trial): study protocol for a randomized controlled trial
Trials2018-07-1632 citations