Vyloy 100 mg powder for concentrate for solution for infusion.
Sponsors
Astellas Pharma Global Development Inc., AstraZeneca AB, UZ Leuven
Conditions
CLDN18.2 positive gastro-esophageal adenocarcinomaEsophageal Cancer Expressing Claudin18.2Gastric AdenocarcinomaGastric CancerGastroesophageal Junction Adenocarcinoma
Phase 2
Phase 3
A Phase 3, Double-blind, Randomized Study of Zolbetuximab in Combination with Pembrolizumab and Chemotherapy (CAPOX or mFOLFOX6) in First-line Treatment of Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma in Participants Whose Tumors are HER2-negative, Claudin (CLDN) 18.2-positive and Programmed Death-ligand 1 (PD-L1)-positive
RecruitingCTIS2024-519773-19-00
Start: 2025-07-31Target: 201Updated: 2026-01-26
A Phase III, Multicentre, Randomised Controlled Study of Sonesitatug vedotin in Combination with Capecitabine with or without Rilvegostomig in First-line Claudin18.2-positive, HER2-negative, Advanced/Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (CLARITY-Gastric 02)
Not yet recruitingCTIS2024-519787-40-00
Target: 126Updated: 2026-06-17