VX-548
Sponsors
Vertex Pharmaceuticals Incorporated
Conditions
Acute PainPainPainful Lumbosacral Radiculopathy
Phase 1
A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-548
CompletedNCT05455502
Start: 2022-07-13End: 2022-09-17Updated: 2024-03-20
A Study to Evaluate the Pharmacokinetic Drug-drug Interactions Between VX-548, Midazolam, and Digoxin
CompletedNCT05541471
Start: 2022-09-22End: 2023-04-28Updated: 2024-03-20
Evaluation of the Pharmacokinetics and Safety of VX-548 in Participants With Mild or Moderate Hepatic Impairment
CompletedNCT05560464
Start: 2022-10-14End: 2023-07-24Updated: 2024-03-20
Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants
CompletedNCT05635110
Start: 2022-12-15End: 2023-06-08Updated: 2024-03-20
Evaluation of the Pharmacokinetics and Safety of VX-548 in Participants With Renal Impairment
CompletedNCT05704556
Start: 2023-02-27End: 2024-03-30Updated: 2024-04-29
A Study to Evaluate the Effect of VX-548 on the QT/QTc Interval in Healthy Participants
CompletedNCT05818852
Start: 2023-04-12End: 2023-06-28Updated: 2024-03-20
A Study to Evaluate the Effect of Food on the Pharmacokinetics of VX-548
CompletedNCT05851157
Start: 2023-05-03End: 2023-11-08Updated: 2024-03-20
A Microneurography Study of NaV1.8 Inhibition in Healthy Adults
CompletedNCT06420765
Start: 2024-05-21End: 2025-04-04Updated: 2025-04-20
Phase 2
A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
CompletedNCT04977336
Start: 2021-07-19End: 2022-03-04Updated: 2025-06-25
A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
CompletedNCT05034952
Start: 2021-08-30End: 2021-12-21Updated: 2024-12-27
Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)
CompletedNCT06176196
Start: 2023-12-13End: 2024-10-16Updated: 2025-10-01