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DRUG8 trials

Sponsors

Johann Wolfgang Goethe University Hospital, Goethe University, Nicola Goekbuget, St. Anna Kinderkrebsforschung

Conditions

Acute Lymphoblastic LeukaemiaAcute Lymphoblastic LeukemiaAdult Acute Lymphocytic LeukemiaBurkitt's LeukemiaBurkitt's LymphomaLarge Cell Anaplastic LymphomaLymphoblastic Leukemia, Acute, Childhood;Lymphoblastic Lymphoma

Phase 2

Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
RecruitingNCT01949129
St. Anna KinderkrebsforschungAcute Lymphoblastic Leukaemia
Start: 2013-04-30End: 2030-04-30Target: 1800Updated: 2024-01-16

Phase 3

ALL-SCT BFM International- HSCT in Children and Adolescents With ALL
NCT01423500
St. Anna KinderkrebsforschungLymphoblastic Leukemia, Acute, Childhood;
Start: 2007-01-31End: 2016-09-30Target: 405Updated: 2015-06-26
Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia
NCT01423747
St. Anna KinderkrebsforschungLymphoblastic Leukemia, Acute, Childhood;
Start: 2003-07-31End: 2016-09-30Target: 400Updated: 2015-06-26
Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment
CompletedNCT02881086
Goethe UniversityAcute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
Start: 2016-08-31End: 2024-12-31Updated: 2025-12-16

Phase 4

Newly Diagnosed Mature B-ALL, Burkitt's Lymphoma and Other High-grade Lymphoma in Adults
CompletedNCT00199082
Nicola GoekbugetBurkitt's Leukemia, Burkitt's Lymphoma, Large Cell Anaplastic Lymphoma +2
Start: 2002-07-31End: 2010-06-30Target: 650Updated: 2022-08-19
German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99)
CompletedNCT00199056
Goethe UniversityAdult Acute Lymphocytic Leukemia
Start: 1999-10-31End: 2005-12-31Target: 225Updated: 2023-03-20
German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults
CompletedNCT00199017
Johann Wolfgang Goethe University HospitalLymphoma, Lymphoblastic
Start: 2004-04-30Target: 75Updated: 2010-08-23
Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab
CompletedNCT00199004
Johann Wolfgang Goethe University HospitalAdult Acute Lymphocytic Leukemia
Start: 2004-04-30End: 2009-03-31Target: 60Updated: 2010-08-23

Related Papers

Refining Busulfan Exposure Enhances Pediatric ALL HSCT Outcomes: Insights from the International FORUM Study.
2026-03-04
Outcome of children with B-cell acute lymphoblastic leukemia with hypodiploidy or BCR::ABL1 fusion undergoing allogeneic HSCT.
2025-11-19
Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM
Blood Advances2024-11-272 citations
<i>Chemotherapy or Stem Cell Transplantation in Adult High Risk Ph/BCR::ABL1-Negative ALL Patients with Early MRD Negativity: Results of the Randomized GMALL Trial 08/2013</i>
Blood2024-11-053 citations
Update on GMALL Trial 08/2013 Shows Durable Favorable Outcome of Newly Diagnosed Adult Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ALL) with Imatinib, Dose-Reduced Induction Followed By Stem Cell Transplantation
Blood2024-11-053 citations
Comparative Results of Pediatric Patients with ALL Receiving Either of Two Different Types of Human Anti-T Lymphocyte Globulin Prior to Hematopoietic Stem Cell Transplantation: Findings from the International Prospective Forum Study
Blood2024-11-05
<i>CNS Irradiation in Adult De Novo B-Precursor ALL / Lbl: Results of the Randomized GMALL T rial 08/2013 Indicate Potential Antileukemic Efficacy</i>
Blood2023-11-02
Comparable Outcome after Busulfan- or Treosulfan-Based Conditioning Regimen in Children Above 4 Years of Age with ALL Undergoing Allogeneic HSCT. Results from the Prospective International Forum-Trial
Blood2023-11-02
Similar Overall Survival and Event-Free Survival for Patients Under or over the Age of 14 Years, but More Chronic Graft Versus Host Disease and Non-Relapse Mortality in the “Older” Patients
Blood2023-11-02
Low rate of nonrelapse mortality in under-4-year-olds with ALL given chemotherapeutic conditioning for HSCT: a phase 3 FORUM study
Blood Advances2023-09-2211 citations
P355: FAVORABLE OUTCOME OF PHILADELPHIA-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA WITH IMATINIB, DOSE-REDUCED INDUCTION FOLLOWED BY ALLOGENEIC STEM CELL TRANSPLANTATION –RESULTS FROM THE GMALL TRIAL 08/13
HemaSphere2023-08-015 citations
Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial
Blood Advances2023-06-0526 citations
First Results of the Risk-Adapted, MRD-Stratified GMALL Trial 08/2013 in 705 Adults with Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma (ALL/LBL)
Blood2021-11-0524 citations
Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study
Journal of Clinical Oncology2020-12-17307 citations
Adults with Philadelphia chromosome–like acute lymphoblastic leukemia frequently have <i>IGH-CRLF2</i> and <i>JAK2</i> mutations, persistence of minimal residual disease and poor prognosis
Haematologica2016-08-25161 citations
Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial
Blood2014-10-31296 citations
Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies.
2012-03-22349 citations