VP-16

DRUG15 trials

Sponsors

H. Lee Moffitt Cancer Center and Research Institute, Ann & Robert H Lurie Children's Hospital of Chicago, New Mexico Cancer Research Alliance, Stanford University, Fondazione Italiana Linfomi - ETS

Conditions

ALLAML, AdultAcute GVHDAcute Lymphobkastic LeukemiaAcute Lymphoblastic LeukemiaAllogeneic, CAR-T, Protein Sequestration, Non-gene EditedB-cell Acute Lymphoblastic LeukemiaB-cell Lymphoma

Phase 1

Natural Killer (NK) Cell Therapy for B-Cell Malignancies

Zhejiang UniversityB-cell Acute Lymphoblastic Leukemia, B-cell Lymphoma

Start: 2021-11-04End: 2024-12-31Target: 24Updated: 2022-05-18

Safety and Efficacy of ThisCART19A Bridging Hematopoietic Stem Cell Transplantation in Patients With Refractory or Relapsed B-cell Acute Lymphoblastic Leukemia

Fundamenta Therapeutics, Ltd.Allogeneic, CAR-T, Protein Sequestration, Non-gene Edited

Start: 2022-10-15End: 2025-07-22Target: 19Updated: 2022-10-12

Natural Killer(NK) Cell Therapy in r/r AML

Zhejiang UniversityAML, Adult

Start: 2022-12-24End: 2025-12-24Target: 18Updated: 2023-01-03

Natural Killer (NK) Cell Therapy Targeting CD33 in Acute Myeloid Leukemia

Zhejiang UniversityAML, Adult

Start: 2022-12-24End: 2025-12-24Target: 19Updated: 2023-01-03

Phase 2

Bone Marrow Transplant in Treating Patients With Hematologic Cancers

CompletedNCT00005797

H. Lee Moffitt Cancer Center and Research InstituteChronic Myeloproliferative Disorders, Leukemia, Multiple Myeloma and Malignant Plasma Cell Neoplasms +2

Start: 1993-03-31End: 2007-07-31Updated: 2020-12-10

Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

CompletedNCT00179920

Ann & Robert H Lurie Children's Hospital of ChicagoRetinal Neoplasms, Retinoblastoma

Start: 1996-04-30End: 2006-09-30Target: 30Updated: 2020-08-05

Study: Treatment of Relapsed Lymphoid Malignancies With an Anti-Angiogenic Approach

TerminatedNCT00250718

New Mexico Cancer Research AllianceCancer, Non-Hodgkin's Lymphoma

Start: 2004-10-31End: 2014-05-31Updated: 2015-08-03

Sirolimus & Mycophenolate Mofetil as GVHD Prophylaxis in Myeloablative, Matched Related Donor HCT

CompletedNCT00350181

Stanford UniversityAcute GVHD, Hematologic Diseases, Leukemia +1

Start: 2006-08-31End: 2010-04-30Updated: 2021-09-23

Ponatinib With Chemotherapy for Young Adults Ph Positive Acute Lymphoblastic Leukemia

PETHEMA FoundationALL

Start: 2016-06-30End: 2023-08-31Updated: 2022-02-18

Envafolimab, Lenvatinib Combined With VP-16 in Platinum-resistant Recurrent Epithelial Ovarian Cancer

Zhongda HospitalOvarian Cancer, Epithelial

Start: 2022-06-30End: 2023-12-30Target: 20Updated: 2022-06-16

Phase 3

Dose Dense Chemotherapy + Rituximab +/-Intensified High Dose Chemoimmunotherapy With Support of Peripheral Autologous Stem Cell in Diffuse Large B-Cell Lymphoma

Fondazione Italiana Linfomi - ETSDiffuse Large B-Cell Lymphoma, IPI≥2

Start: 2006-01-31End: 2013-09-30Target: 399Updated: 2011-02-15

Phase 4

LAL-BR/2001: Study Treatment to Low Risk ALL

CompletedNCT00526175

PETHEMA FoundationAcute Lymphoblastic Leukemia

Start: 2001-06-30End: 2015-12-31Target: 150Updated: 2016-01-20

HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL

Nanfang Hospital, Southern Medical UniversityAcute Lymphoblastic Leukemia

Start: 2013-05-31End: 2015-12-31Target: 100Updated: 2015-10-09

Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia

CompletedNCT02036489

PETHEMA FoundationAcute Lymphobkastic Leukemia

Start: 2008-01-31End: 2019-12-01Updated: 2020-03-05

Unknown Phase

Rituxan + BEAM and Auto Stem Cell Transplant for High Risk Lymphoma or Hodgkin's Disease

CompletedNCT01702961

Baylor College of MedicineHodgkin's Disease, Lymphoma

Start: 2002-06-30End: 2017-01-31Updated: 2018-12-19

Related Papers

Combination therapy for platinum-resistant ovarian cancer: a novel at-home regimen with envafolimab, lenvatinib, and etoposide

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Efficacy and safety of envafolimab plus lenvatinib combined with etoposide in recurrent ovarian, peritoneal, and fallopian tube cancer: An open-label, single-arm study—The ENLEN-OC-001 study.

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