Voxelotor
Sponsors
Pfizer, University of Illinois at Chicago, Elizabeth Yang, MD, PhD, Emory University, Duke University
Conditions
Acute Lung InjuryEnd Stage Lung DiseaseGenetic Diseases
PaediatricsHaematological DisordersHaematological Disorders
PaediatricsHaematological Disorders
Sickle Cell DiseaseSickle Cell AnemiaSickle Cell Anemia in Children
Phase 1
A Voxelotor for Sickle Cell Anemia Patients at Highest Risk for Progression of Chronic Kidney Disease
TerminatedNCT04335721
Start: 2021-03-16End: 2024-10-07Updated: 2025-04-03
Voxelotor CYP and Transporter Cocktail Interaction Study
CompletedNCT05981365
Start: 2023-04-17End: 2023-10-04Updated: 2024-11-22
Phase 2
Study to Evaluate the Effect of GBT440 in Pediatrics With Sickle Cell Disease
TerminatedNCT02850406
Start: 2016-07-05End: 2023-10-02Updated: 2025-08-15
Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCD
TerminatedNCT04247594
Start: 2020-01-09End: 2021-06-08Updated: 2023-11-21
The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia
TerminatedNCT05018728
Start: 2022-03-28End: 2024-10-22Updated: 2025-12-12
Voxelotor for Improving Oxygen Saturation in Adults
TerminatedNCT05289570
Start: 2022-05-03End: 2023-07-04Updated: 2024-07-24
Assessing Physical Function in Sickle Cell Patients Taking Voxelotor
CompletedNCT06023199
Start: 2023-10-23End: 2026-03-05Updated: 2026-08-31
Phase 3
Study to Evaluate the Effect of Voxelotor Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE)
CompletedNCT03036813
Start: 2016-12-31End: 2019-10-08Updated: 2023-07-27
Study to Assess the Effect of Long-term Treatment With Voxelotor in Participants Who Have Completed Treatment in Study GBT440-031
TerminatedNCT03573882
Start: 2018-06-06End: 2024-11-12Updated: 2025-11-18
Open-Label Extension of Voxelotor
TerminatedNCT04188509
Start: 2019-11-18End: 2024-11-01Updated: 2025-11-13
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
TerminatedNCT04218084
Start: 2020-11-11End: 2024-11-06Updated: 2026-03-10
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Voxelotor (GBT440) in Pediatric Participants with Sickle Cell Disease (HOPE Kids 2)
Active, not recruitingPACTR202007786627403
Start: 2020-10-31Target: 224Updated: 2026-08-03
Resolution of Sickle Cell Leg Ulcers with Voxelotor (RESOLVE)
Active, not recruitingPACTR202102669041711
Start: 2021-09-07Target: 80Updated: 2026-08-03
Open-Label Extension of Voxelotor
RecruitingPACTR202209867711506
Start: 2022-12-11Target: 600Updated: 2026-08-03
An Open Label Extension Study of Voxelotor (GBT440) Administered Orally to Participants with Sickle Cell Disease Who Have Participated in Voxelotor Clinical Trials
Active, not recruitingPACTR202509627939569
Start: 2019-01-21Target: 340Updated: 2026-09-14
Phase 4
Unknown Phase
Related Papers
1 more papers not shown