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Voxelotor

DRUG19 trials

Sponsors

Pfizer, University of Illinois at Chicago, Elizabeth Yang, MD, PhD, Emory University, Duke University

Conditions

Acute Lung InjuryEnd Stage Lung DiseaseGenetic Diseases PaediatricsHaematological DisordersHaematological Disorders PaediatricsHaematological Disorders Sickle Cell DiseaseSickle Cell AnemiaSickle Cell Anemia in Children

Phase 1

Phase 2

Phase 3

Study to Evaluate the Effect of Voxelotor Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE)
CompletedNCT03036813
PfizerSickle Cell Disease
Start: 2016-12-31End: 2019-10-08Updated: 2023-07-27
Study to Assess the Effect of Long-term Treatment With Voxelotor in Participants Who Have Completed Treatment in Study GBT440-031
TerminatedNCT03573882
PfizerSickle Cell Disease
Start: 2018-06-06End: 2024-11-12Updated: 2025-11-18
Open-Label Extension of Voxelotor
TerminatedNCT04188509
PfizerSickle Cell Disease
Start: 2019-11-18End: 2024-11-01Updated: 2025-11-13
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
TerminatedNCT04218084
PfizerSickle Cell Disease
Start: 2020-11-11End: 2024-11-06Updated: 2026-03-10
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Voxelotor (GBT440) in Pediatric Participants with Sickle Cell Disease (HOPE Kids 2)
Active, not recruitingPACTR202007786627403
Global Blood TherapeuticsHaematological Disorders Paediatrics
Start: 2020-10-31Target: 224Updated: 2026-08-03
Resolution of Sickle Cell Leg Ulcers with Voxelotor (RESOLVE)
Active, not recruitingPACTR202102669041711
Global Blood Therapeutics IncGenetic Diseases Paediatrics
Start: 2021-09-07Target: 80Updated: 2026-08-03
Open-Label Extension of Voxelotor
RecruitingPACTR202209867711506
Global Blood Therapeutics incHaematological Disorders Sickle Cell Disease
Start: 2022-12-11Target: 600Updated: 2026-08-03
An Open Label Extension Study of Voxelotor (GBT440) Administered Orally to Participants with Sickle Cell Disease Who Have Participated in Voxelotor Clinical Trials
Active, not recruitingPACTR202509627939569
Global Blood TherapeuticsHaematological Disorders
Start: 2019-01-21Target: 340Updated: 2026-09-14

Phase 4

Unknown Phase

Related Papers

New England Journal of Medicine2019-06-14579 citations

1 more papers not shown