Volume Modulated Arc Therapy

RADIATION8 trials

Conditions

Acute LeukemiaAnatomic Stage IV Breast Cancer AJCC v8Astrocytoma, IDH-Mutant, Grade 3Biochemically Recurrent Prostate CarcinomaHead and Neck CarcinomaLarynxLip, Oral Cavity and PharynxLocalized Head and Neck Carcinoma

Early Phase 1

Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer

CompletedNCT03162731

Sidney Kimmel Cancer Center at Thomas Jefferson UniversityLarynx, Lip, Oral Cavity and Pharynx

Start: 2017-05-11End: 2022-11-16Updated: 2025-04-29

Phase 1

TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT

Active, not recruitingNCT04281199

City of Hope Medical CenterAcute Leukemia, Myelodysplastic Syndrome

Start: 2020-02-28End: 2026-07-14Updated: 2025-09-16

Phase 2

Single Fraction or Multi-fraction Palliative Radiation Therapy for the Improvement of Quality of Life in Patients With Metastatic Gynecologic Cancers

Active, not recruitingNCT04516135

M.D. Anderson Cancer CenterMetastatic Malignant Female Reproductive System Neoplasm

Start: 2021-01-11End: 2029-12-31Updated: 2026-02-25

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

RecruitingNCT06518057

University of WashingtonAnatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma +2

Start: 2025-03-03End: 2027-12-30Target: 22Updated: 2025-12-11

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

RecruitingNCT06910761

City of Hope Medical CenterAnatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma +2

Start: 2025-05-05End: 2028-10-02Target: 35Updated: 2025-12-08

Phase 3

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

RecruitingNCT04423211

ECOG-ACRIN Cancer Research GroupBiochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma, Prostate Adenocarcinoma +1

Start: 2020-10-08End: 2032-12-31Target: 804Updated: 2026-04-03

Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

Not yet recruitingNCT07215910

Alliance for Clinical Trials in OncologyAstrocytoma, IDH-Mutant, Grade 3

Start: 2025-10-20End: 2040-01-31Target: 408Updated: 2025-10-14

Unknown Phase

Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatment (PULS-Pal)

RecruitingNCT06572423

Jonsson Comprehensive Cancer CenterHead and Neck Carcinoma, Localized Head and Neck Carcinoma, Metastatic Head and Neck Carcinoma +1

Start: 2024-10-25End: 2029-12-16Target: 43Updated: 2026-02-05

Neuro-Oncology Advances2025-08-01

A phase II study of personalized ultrafractionated stereotactic adaptive radiotherapy for palliative head and neck cancer treatment (PULS-Pal): a single-arm clinical trial protocol.

2024-12-213 citations

Nivolumab and ipilimumab in combination with radiotherapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck

Journal for ImmunoTherapy of Cancer2023-08-0115 citations

Phase III study of local or systemic therapy intensification directed by PET in prostate cancer patients with post-prostatectomy biochemical recurrence (INDICATE): ECOG-ACRIN EA8191.

Journal of Clinical Oncology2023-06-011 citations

Phase III study of local or systemic therapy intensification directed by PET in prostate cancer patients with post-prostatectomy biochemical recurrence (INDICATE): ECOG-ACRIN EA8191.

Journal of Clinical Oncology2023-02-20

Phase III study of local or systemic therapy INtensification DIrected by PET in prostate CAncer patients with post-prostaTEctomy biochemical recurrence (INDICATE): ECOG-ACRIN EA8191.

Journal of Clinical Oncology2021-05-203 citations

PET-directed local or systemic therapy intensification in prostate cancer patients with post-prostatectomy biochemical recurrence: A trial of the ECOG-ACRIN Cancer Research Group (EA8191).

Journal of Clinical Oncology2021-02-202 citations

Nivolumab (Nivo) and ipilimumab (Ipi) in combination with radiotherapy (RT) in high-risk patients (pts) with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN).

Journal of Clinical Oncology2020-05-206 citations

Safety of nivolumab and ipilimumab in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN).

Journal of Clinical Oncology2019-05-206 citations

Nivolumab and ipilimumab in combination with radiotherapy in patients with locally advanced head and neck cancer

Annals of Oncology2018-10-011 citations