Volanesorsen

DRUG6 trials

Conditions

Abnormalities, CardiovascularFamilial ChylomicronemiaFamilial Chylomicronemia SyndromeFamilial Partial LipodystrophyHyperlipoproteinemia Type 1HypertriglyceridemiaLipoprotein Lipase Deficiency

Phase 1

A Study to Evaluate the Effect of Volanesorsen on Cardiac Repolarization Conducted in Healthy Volunteers

CompletedNCT02910635

Ionis Pharmaceuticals, Inc.Abnormalities, Cardiovascular

Start: 2016-09-19End: 2016-12-20Updated: 2022-01-28

Phase 2

The BROADEN Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Partial Lipodystrophy

TerminatedNCT02527343

Akcea TherapeuticsFamilial Partial Lipodystrophy

Start: 2015-12-28End: 2019-11-13Updated: 2021-10-18

Phase 3

The APPROACH Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Patients With Familial Chylomicronemia Syndrome

CompletedNCT02211209

Ionis Pharmaceuticals, Inc.Familial Chylomicronemia Syndrome

Start: 2014-12-31End: 2017-03-28Updated: 2022-04-13

The COMPASS Study: A Study of Volanesorsen (Formally ISIS-APOCIIIRx) in Patients With Hypertriglyceridemia

CompletedNCT02300233

Ionis Pharmaceuticals, Inc.Hypertriglyceridemia

Start: 2015-02-05End: 2017-01-24Updated: 2022-04-13

The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Chylomicronemia Syndrome

CompletedNCT02658175

Akcea TherapeuticsFamilial Chylomicronemia Syndrome, Hyperlipoproteinemia Type 1, Lipoprotein Lipase Deficiency

Start: 2015-12-23End: 2020-01-15Updated: 2021-08-26

Unknown Phase

Volanesorsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS)

NCT03544060

Akcea TherapeuticsFamilial Chylomicronemia

Updated: 2021-09-16

Related Papers

Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

2021-03-30152 citations

Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome

New England Journal of Medicine2019-08-07628 citations

Clinical and biochemical features of different molecular etiologies of familial chylomicronemia.

2018-04-04115 citations