Vivotif Typhoid Oral Vaccine

DRUG4 trials

Sponsors

University of Maryland, Baltimore, USDA, Western Human Nutrition Research Center

Conditions

InflammationIntestinal PermeabilityRisk ReductionTyphoid FeverTyphoid VaccinationTyphoid and/or Cholera VaccinationVaccine

Early Phase 1

Induction of Gut Permeability by an Oral Vaccine

Active, not recruitingNCT04083950

USDA, Western Human Nutrition Research CenterInflammation, Intestinal Permeability, Typhoid Fever +1

Start: 2019-12-04End: 2026-09-30Updated: 2025-11-24

Phase 4

CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera

RecruitingNCT03705585

University of Maryland, BaltimoreTyphoid and/or Cholera Vaccination

Start: 2018-11-05End: 2029-05-31Target: 240Updated: 2026-09-04

CVD 37000: Immunity and Microbiome Studies at Intestinal and Systemic Sites in Ty21a Vaccinated Adults

Active, not recruitingNCT03970304

University of Maryland, BaltimoreTyphoid Vaccination

Start: 2013-10-24End: 2027-08-01Updated: 2026-01-07

Blood Donor CVD 5000

RecruitingNCT03971669

University of Maryland, BaltimoreRisk Reduction

Start: 2004-01-16End: 2030-06-30Target: 150Updated: 2026-03-27

Related Papers

Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans

Immunity & Ageing2021-04-1913 citations

Oral typhoid vaccine Ty21a elicits antigen-specific resident memory CD4<sup>+</sup> T cells in the human terminal ileum lamina propria and epithelial compartments.

2020-02-2517 citations