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vibostolimab

BIOLOGICAL10 trials

Sponsors

Merck Sharp & Dohme LLC

Conditions

Carcinoma, Non-Small-Cell LungMelanomaNeoplasm MetastasisNeoplasmsPD-1 refractory melanomaStage IIIB or IIIC or IIID melanomanon-small cell lung cancer

Phase 1

Study of Vibostolimab Alone and in Combination With Pembrolizumab in Advanced Solid Tumors (MK-7684-001) ( KEYVIBE-001)
CompletedNCT02964013
Merck Sharp & Dohme LLCNeoplasms
Start: 2016-12-13End: 2024-07-24Updated: 2025-10-14
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
RecruitingNCT04165070
Merck Sharp & Dohme LLCCarcinoma, Non-Small-Cell Lung
Start: 2019-12-19End: 2032-02-13Target: 450Updated: 2026-03-16
Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)
CompletedNCT04303169
Merck Sharp & Dohme LLCMelanoma
Start: 2020-06-26End: 2025-09-24Updated: 2025-10-27
Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)
CompletedNCT04305041
Merck Sharp & Dohme LLCMelanoma
Start: 2020-06-26End: 2025-08-25Updated: 2025-08-29
Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)
Active, not recruitingNCT04305054
Merck Sharp & Dohme LLCMelanoma
Start: 2020-07-01End: 2026-04-20Target: 315Updated: 2025-08-29
A Phase 1/2 Open-label, Rolling-arm, Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants with Melanoma (KEYMAKER-U02): Substudy 02A
CompletedCTIS2023-506312-41-00
Merck Sharp & Dohme LLCPD-1 refractory melanoma
Start: 2020-07-30End: 2025-08-22Target: 58Updated: 2025-09-01
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants with Melanoma (KEYMAKER-U02): Substudy 02C
CompletedCTIS2023-506314-51-00
Merck Sharp & Dohme LLCStage IIIB or IIIC or IIID melanoma
Start: 2020-07-31End: 2025-09-09Target: 29Updated: 2025-09-09
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizuma Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02B
RecruitingCTIS2023-506313-21-00
Merck Sharp & Dohme LLCPD-1 refractory melanoma
Start: 2020-08-03Target: 71Updated: 2025-11-21
A Study of Pembrolizumab in Combination With Investigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01B/LIGHTBEAM-U01)
WithdrawnNCT06395090
Merck Sharp & Dohme LLCNeoplasm Metastasis
Start: 2025-01-15End: 2029-06-30Updated: 2025-04-08

Phase 2

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