Vibegron
Sponsors
Urovant Sciences GmbH, Hinata Nobuyuki, Merck Sharp & Dohme LLC, Wake Forest University Health Sciences
Conditions
Irritable Bowel SyndromeNeurogenic Detrusor OveractivityNeurogenic Detrusor Overactivity (NDO)ObesityOveractive BladderOveractive Urinary BladderPatients undergoing new ureteral stenting for upper urinary tract stenosis
stent-related symptoms, overactive bladder, ureteral stentUrinary Bladder, Overactive
Phase 1
A Study of the Pharmacokinetics and Pharmacodynamics of Vibegron (MK-4618) in Women With Overactive Bladder (MK-4618-004)
TerminatedNCT01500382
Start: 2012-02-27End: 2013-01-02Updated: 2018-12-24
A Single-Dose Study of the Pharmacokinetics of Vibegron (MK-4618) in Adults With Hepatic Insufficiency (MK-4618-013)
CompletedNCT01737684
Start: 2013-01-15End: 2013-06-14Updated: 2018-12-24
Phase 2
A Study of the Efficacy and Safety of Vibegron (MK-4618) in Participants With Overactive Bladder (OAB) (MK-4618-008)
CompletedNCT01314872
Start: 2011-03-31End: 2013-10-10Updated: 2019-02-04
Study to Evaluate the Efficacy and Safety of Vibegron Administered Orally for 12 Weeks to Women With Irritable Bowel Syndrome
CompletedNCT03806127
Start: 2018-12-31End: 2020-10-06Updated: 2021-08-02
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
RecruitingNCT05491525
Start: 2022-10-12End: 2030-09-01Target: 71Updated: 2026-06-15
A Phase 2/3, Open-label, Baseline-controlled, Multicenter, Long-term Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age with Neurogenic Detrusor Overactivity (NDO) on Clean Intermittent Catheterization (CIC)
RecruitingCTIS2024-513995-16-00
Start: 2023-07-28Target: 48Updated: 2025-08-11
Phase 3
A Study to Examine the Safety and Efficacy of a New Drug in Patients With Symptoms of Overactive Bladder (OAB)
CompletedNCT03492281
Start: 2018-03-26End: 2019-02-04Updated: 2021-03-04
An Extension Study to Examine the Safety and Tolerability of a New Drug in Patients With Symptoms of Overactive Bladder (OAB).
CompletedNCT03583372
Start: 2018-06-14End: 2019-07-25Updated: 2021-03-18
Study to Evaluate the Efficacy, Safety and Tolerability of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic Hyperplasia (BPH)
CompletedNCT03902080
Start: 2019-03-26End: 2023-06-15Updated: 2024-08-07
Extension Study of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic Hyperplasia
CompletedNCT04103450
Start: 2019-09-19End: 2022-07-29Updated: 2024-08-21
Vibegron for ENergy Thinking and Resilience in Aging
Not yet recruitingNCT06987383
Start: 2026-10-01End: 2028-07-01Target: 40Updated: 2026-09-03
Unknown Phase
Composur: Study to Understand the Performance of Vibegron in Participants with Overactive Bladder (OAB)
CompletedNCT05067478
Start: 2021-10-28End: 2024-07-26Updated: 2024-12-27
Preventive Effects of Vibegron on Ureteral Stent-Related Symptoms
RecruitingJPRN-jRCTs061240140
Start: 2025-05-12Target: 100Updated: 2026-06-29