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VIB4920

DRUG6 trials

Sponsors

Amgen, National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

Adult Onset Rheumatoid ArthritisAllograftsHighly Sensitized Patients on Waiting List for Kidney TransplantationKidney TransplantationLupus NephritisRejection; Transplant, KidneyRheumatoid ArthritisSjögren's Syndrome

Phase 1

A Phase 1b Study of MEDI4920 in Participants With Adult-onset Rheumatoid Arthritis
CompletedNCT02780388
AmgenAdult Onset Rheumatoid Arthritis
Start: 2016-05-12End: 2018-08-09Updated: 2024-12-27

Phase 2

A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant
CompletedNCT04046549
AmgenAllografts, Kidney Transplantation, Rejection; Transplant, Kidney +1
Start: 2019-10-30End: 2023-03-22Updated: 2024-12-27
A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome
CompletedNCT04129164
AmgenSjögren's Syndrome
Start: 2019-12-09End: 2023-03-10Updated: 2025-04-30
A Study to Evaluate the Safety and Efficacy of VIB4920 in Participants With Rheumatoid Arthritis
CompletedNCT04163991
AmgenRheumatoid Arthritis
Start: 2019-12-09End: 2021-12-28Updated: 2024-12-17
Safety and Tolerability of Inebilizumab, VIB4920, or the Combination in Highly Sensitized Candidates Awaiting Kidney Transplantation From a Deceased Donor
WithdrawnNCT04174677
AmgenHighly Sensitized Patients on Waiting List for Kidney Transplantation
Start: 2019-12-27End: 2022-04-30Updated: 2024-06-21
VIBRANT: VIB4920 for Active Lupus Nephritis
RecruitingNCT05201469
National Institute of Allergy and Infectious Diseases (NIAID)Lupus Nephritis
Start: 2022-05-16End: 2027-03-31Target: 74Updated: 2025-12-19

Related Papers

CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial
Nature Medicine2024-06-0145 citations
The MIDORA trial: a phase II, randomised, double-blind, placebo-controlled, mechanistic insight and dosage optimisation study of the efficacy and safety of dazodalibep in patients with rheumatoid arthritis
RMD Open2023-08-0113 citations
Dazodalibep improves dryness, fatigue, and pain in patients with Sjögren’s syndrome with a high symptom burden
2023-07-30