Venglustat

DRUG6 trials

Sponsors

Genzyme, a Sanofi Company, Sanofi

Conditions

Disorders of Sphingolipid MetabolismGaucher's Disease Type IIIHealthy VolunteersPolycystic Kidney, Autosomal Dominant

Phase 1

Excretion Balance, Pharmacokinetics, and Metabolism Following of [14C]-Venglustat Administration in Healthy Male Subjects

CompletedNCT05238714

Genzyme, a Sanofi CompanyDisorders of Sphingolipid Metabolism, Healthy Volunteers

Start: 2020-05-26End: 2020-06-26Updated: 2025-09-17

A Study of the Safety, Tolerability, and Bioequivalence of Orally Administered Venglustat in Healthy Adult Participants

CompletedNCT06418607

SanofiHealthy Volunteers

Start: 2020-06-23End: 2020-07-13Updated: 2024-05-17

A Study of the Safety, Tolerability, and Bioavailability of Orally Administered Venglustat in Healthy Adult Participants

CompletedNCT06418620

SanofiHealthy Volunteers

Start: 2020-06-18End: 2020-08-07Updated: 2024-05-17

A Study of the Safety, Tolerability, and Pharmacokinetics of Orally Administered Venglustat and Itraconazole in Healthy Adult Male Participants

CompletedNCT06421714

Genzyme, a Sanofi CompanyHealthy Volunteers

Start: 2018-08-16End: 2018-10-14Updated: 2024-05-20

Phase 2

A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients

TerminatedNCT03523728

Genzyme, a Sanofi CompanyPolycystic Kidney, Autosomal Dominant

Start: 2018-10-04End: 2021-08-03Updated: 2023-02-03

Phase 3

Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3

Active, not recruitingNCT05222906

SanofiGaucher's Disease Type III

Start: 2022-04-18End: 2026-10-30Updated: 2025-10-17

Related Papers

Pharmacokinetics, Safety, and Tolerability of Single-Dose Orally Administered Venglustat in Healthy Chinese Volunteers.

2023-06-031 citations

Venglustat, a Novel Glucosylceramide Synthase Inhibitor, in Patients at Risk of Rapidly Progressing ADPKD: Primary Results of a Double-Blind, Placebo-Controlled, Phase 2/3 Randomized Clinical Trial.

2022-12-1711 citations

The STAGED-PKD 2-Stage Adaptive Study With a Patient Enrichment Strategy and Treatment Effect Modeling for Improved Study Design Efficiency in Patients With ADPKD

Kidney Medicine2022-08-278 citations