Venclyxto
Sponsors
University Of Cologne, F. Hoffmann-La Roche AG, ASST Grande Ospedale Metropolitano Niguarda, First Affiliated Hospital of Zhejiang University
Conditions
Acute Myeloid LeukemiaAdvanced MalignanciesChronic Lymphocytic Leukemia (CLL)Myelodysplastic SyndromesRelapsed/refractory chronic lymphocytic leukemiaRichter syndrome of chronic lymphocytic leukemia
Phase 2
Prolonged Ultra Low-dose Decitabine Plus Venetoclax for Primary Diagnosed Elderly AMLK/MDS
RecruitingNCT06046313
Start: 2023-10-19End: 2026-10-19Target: 120Updated: 2024-03-05
A prospective, open-label, multicenter phase-II-trial to evaluate the efficacy and safety of a sequential regimen of Bendamustine followed by Obinutuzumab (GA101), Zanubrutinib (BGB-3111) and Venetoclax (ABT-199) in patients with relapsed/refractory CLL - (CLL2-BZAG)
Active, not recruitingCTIS2022-502201-16-00
Start: 2020-09-30Target: 42Updated: 2026-01-12
A Multi-Center, Open Label, Uncontrolled, Phase II Clinical Trial Evaluating the Safety and Efficacy of Venetoclax in Combination with Atezolizumab and Obinutuzumab in Richter Transformation of CLL
CompletedCTIS2024-516675-32-00
Start: 2019-10-08End: 2025-11-30Target: 14Updated: 2025-11-13
Phase 3
A Prospective, Open-Label, Multicenter Randomized Phase III Trial to Compare the Efficacy and Safety of a Combined Regimen of Obinutuzumab and Venetoclax (GDC-0199/ABT-199) Versus Obinutuzumab and Chlorambucil in Previously Untreated Patients with CLL and Coexisting Medical Conditions
CompletedCTIS2023-504034-22-00
Start: 2014-12-18End: 2025-08-06Target: 267Updated: 2025-06-27
An open label, multicenter extension study in patients previously enrolled in a Genentch and/or F. Hoffmann-La Roche Ltd sponsored atezolizumab study (IMBRELLA B)
Active, not recruitingCTIS2023-506184-34-00
Start: 2019-08-09Target: 104Updated: 2025-11-10
A Prospective, Open-Label, Multicenter Randomized Phase III Study to Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine and Rituximab (BR) in FIT Patients with previously untreated Chronic Lymphocytic Leukemia (CLL) without DEL(17P) or TP53 Mutation
CompletedCTIS2023-504036-17-00
Start: 2020-05-07End: 2025-03-18Target: 121Updated: 2025-04-17