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Vectibix 20 mg/ml concentrate for solution for infusion

DRUG12 trials

Sponsors

Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, IRCCS Istituto Nazionale Tumori Fondazione Pascale, Unicancer, Amgen Inc., Gruppo Oncologico Del Nord Ovest

Conditions

Advanced solid tumorColorectal Cancer (CRC)Colorectal cancer and metastatic disease limited to the liver with bad prognosis.Colorectal cancer spread at distanceInflammatory bowel diseaseMultiple myelomaNon-Hodgkin lymphomaOncology

Phase 2

PANIRINOX : Phase II randomized study comparing FOLFIRINOX + Panitumumab versus mFOLFOX6 + Panitumumab in metastatic colorectal cancer patients selected by RAS and B-RAF status from circulating DNA analysis
Active, not recruitingCTIS2024-510645-34-00
UnicancerRAS and B-RAF wild-type metastatic colorectal cancer. RAS and B-RAF mutation will be determined using circulating cell-free DNA (ccfDNA) by IntPlex method
Start: 2017-06-28Target: 225Updated: 2024-03-22
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis StichtingAdvanced solid tumor, Multiple myeloma, Non-Hodgkin lymphoma +1
Start: 2016-07-25Target: 3000Updated: 2025-12-19
Randomized phase 2 study of Valproic acid combinEd with rechallenge anti-EGFR based regimen regimens in pretreated patients with RAS/BRAF wild-type metastatic colorectal cancer (VICTORIA)
RecruitingCTIS2024-514420-16-00
IRCCS Istituto Nazionale Tumori Fondazione PascaleRAS/BRAF wild-type metastatic colorectal cancer
Start: 2024-12-18Target: 130Updated: 2025-11-27
Randomized phase II study of PAnitumumab REchallenge followed by REgorafenib versus the reverse sequence in RAS and BRAF wild-type chemorefractory metastatic colorectal cancer patients. The PARERE trial
Active, not recruitingCTIS2024-513296-41-00
Gruppo Oncologico Del Nord OvestColorectal cancer spread at distance, RAS BRAF wild type pretreatted
Start: 2020-12-03Target: 214Updated: 2024-09-16
Randomized and multicentre Phase II study of FOLFOX6m + monoclonal Ab (anti-EGFR or bevacizumab) alone or in combination with hepatic chemoembolization (Lifepearls-Irinotecan) in patients with colorectal cancer and metastatic disease limited to the liver with bad prognosis.
Active, not recruitingCTIS2024-517782-16-00
Grupo Espanol Multidisciplinar En Cancer DigestivoColorectal cancer and metastatic disease limited to the liver with bad prognosis.
Start: 2024-10-10Target: 45Updated: 2025-12-09
Systemic antitumor treatment with or without pressurized intraperitoneal aerosol chemotherapy (PIPAC) for colon peritoneal metastases – a multicentre phase II randomized trial (PIPOX02)
RecruitingCTIS2024-514560-10-00
Institut De Cancerologie De L OuestPatients with newly diagnosed advanced peritoneal metastasis from colorectal cancer
Start: 2025-06-12Target: 114Updated: 2024-10-11
Prospective, randomized, open, multicenter Phase II trial to investigate the efficacy of trifluridine/tipiracil plus panitumumab versus trifluridine/tipiracil plus bevacizumab as first-line treatment of metastatic colorectal cancer - FIRE-8 - AIO-KRK/YMO-0519
RecruitingCTIS2024-513723-16-00
Charite Universitaetsmedizin Berlin KöRmetastatic colorectal cancer
Start: 2021-10-21Target: 153Updated: 2025-11-12
FFCD 1605- OPTIPRIME: A phase II study evaluating FOLFOX + panitumumab according to a ‘stop-and-go’ strategy with a reintroduction loop after progression on fluoropyrimidine as maintenance treatment, as the first line in patients with metastatic colorectal adenocarcinoma without a RAS mutation
CompletedCTIS2024-518740-20-00
Fondation Franc.Cancerologie Digestivemetastatic colorectal adenocarcinoma
Start: 2018-04-26End: 2025-05-19Target: 118Updated: 2024-11-14
ENGIC - 01 COLOSOTO: A single-arm phase II study evaluating 5-fluorouracil plus Panitumumab (anti-EGFR) and Sotorasib (KRAS G12C inhibitor) in first-line treatment of patients non-eligible for a doublet/triplet chemotherapy with advanced unresectable KRAS G12C mutated colorectal adenocarcinoma
RecruitingCTIS2024-514030-20-00
Fondation Franc.Cancerologie Digestivecolorectal cancer
Start: 2025-08-29Target: 37Updated: 2026-01-13

Phase 3

Phase 4

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