Vectibix 20 mg/ml concentrate for solution for infusion
Sponsors
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, IRCCS Istituto Nazionale Tumori Fondazione Pascale, Unicancer, Amgen Inc., Gruppo Oncologico Del Nord Ovest
Conditions
Advanced solid tumorColorectal Cancer (CRC)Colorectal cancer and metastatic disease limited to the liver with bad prognosis.Colorectal cancer spread at distanceInflammatory bowel diseaseMultiple myelomaNon-Hodgkin lymphomaOncology
Phase 2
PANIRINOX : Phase II randomized study comparing FOLFIRINOX + Panitumumab versus mFOLFOX6 + Panitumumab in metastatic colorectal cancer patients selected by RAS and B-RAF status from circulating DNA analysis
Active, not recruitingCTIS2024-510645-34-00
Start: 2017-06-28Target: 225Updated: 2024-03-22
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Start: 2016-07-25Target: 3000Updated: 2025-12-19
Randomized phase 2 study of Valproic acid combinEd with rechallenge anti-EGFR based regimen regimens in pretreated patients with RAS/BRAF wild-type metastatic colorectal cancer (VICTORIA)
RecruitingCTIS2024-514420-16-00
Start: 2024-12-18Target: 130Updated: 2025-11-27
Randomized phase II study of PAnitumumab REchallenge followed by REgorafenib versus the reverse sequence in RAS and BRAF wild-type chemorefractory metastatic colorectal cancer patients. The PARERE trial
Active, not recruitingCTIS2024-513296-41-00
Start: 2020-12-03Target: 214Updated: 2024-09-16
Randomized and multicentre Phase II study of FOLFOX6m + monoclonal Ab (anti-EGFR or bevacizumab) alone or in combination with hepatic chemoembolization (Lifepearls-Irinotecan) in patients with colorectal cancer and metastatic disease limited to the liver with bad prognosis.
Active, not recruitingCTIS2024-517782-16-00
Start: 2024-10-10Target: 45Updated: 2025-12-09
Systemic antitumor treatment with or without pressurized intraperitoneal aerosol chemotherapy (PIPAC) for colon peritoneal metastases – a multicentre phase II randomized trial (PIPOX02)
RecruitingCTIS2024-514560-10-00
Start: 2025-06-12Target: 114Updated: 2024-10-11
Prospective, randomized, open, multicenter Phase II trial to investigate the efficacy of trifluridine/tipiracil plus panitumumab versus trifluridine/tipiracil plus bevacizumab as first-line treatment of metastatic colorectal cancer - FIRE-8 - AIO-KRK/YMO-0519
RecruitingCTIS2024-513723-16-00
Start: 2021-10-21Target: 153Updated: 2025-11-12
FFCD 1605- OPTIPRIME: A phase II study evaluating FOLFOX + panitumumab according to a ‘stop-and-go’ strategy with a reintroduction loop after progression on fluoropyrimidine as maintenance treatment, as the first line in patients with metastatic colorectal adenocarcinoma without a RAS mutation
CompletedCTIS2024-518740-20-00
Start: 2018-04-26End: 2025-05-19Target: 118Updated: 2024-11-14
ENGIC - 01 COLOSOTO: A single-arm phase II study evaluating 5-fluorouracil plus Panitumumab (anti-EGFR) and Sotorasib (KRAS G12C inhibitor) in first-line treatment of patients non-eligible for a doublet/triplet chemotherapy with advanced unresectable KRAS G12C mutated colorectal adenocarcinoma
RecruitingCTIS2024-514030-20-00
Start: 2025-08-29Target: 37Updated: 2026-01-13
Phase 3
Randomized phase 3 study of intermittent or continuous Panitumumab plus FOLFIRI for first-line treatment of patients with unresectable left sided RAS/B-RAF wild-type metastatic colorectal cancer (IMPROVE-2 trial)
RecruitingCTIS2023-509551-14-00
Start: 2024-06-12Target: 500Updated: 2025-08-04
A Phase 3 Multicenter, Randomized, Openlabel, Active-controlled Study of Sotorasib and Panitumumab Versus Investigator’s Choice (Trifluridine and Tipiracil, or Regorafenib) for the Treatment of Previously Treated Metastatic Colorectal Cancer Subjects with KRAS p.G12C Mutation
Active, not recruitingCTIS2024-511187-81-00
Start: 2022-03-28Target: 99Updated: 2025-07-17