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DRUG2 trials

Sponsors

Institute Of Tropical Medicine, UZ Brussel

Conditions

Procalcitonin concentration ≥0·5 ng/mL or white blood cell count ≥12×10^9 per L (all without other plausible sourceUrinary tract infection with systemic involvement (UTI: definiteattributable to the UTI: • Temperature ≥38°C • Flank pain or costovertebral angle tenderness • Systolic blood pressure <90 mmHg without alternative cause • Significant elevation of inflammatory markers related to the UTI: o C-reactive protein concentration ≥50 mg/Lbacterial sexually transmitted infectionsbased on at least history and examination). • Bacteraemia with the same pathogen as isolated from urine cultureor possible UTI according to the diagnostic criteria of the research reference standard for UTI proposed by Bilsen et al (see reference 19 in protocol)). Systemic involvement: one or more of the followingprobable

Phase 3

A double-blind, multi-centre, randomized, placebo-controlled cross-over clinical trial to assess the efficacy of doxyPEP in reducing the incidence of bacterial STIs among MSM and TGW living with HIV in Belgium (DoxHIV study)
RecruitingCTIS2025-521153-16-00
Institute Of Tropical Medicinebacterial sexually transmitted infections
Start: 2025-12-05Target: 200Updated: 2025-06-02
A randomized controlled non-inferiority trial comparing 7 versus 14 days of ciprofloxacin for male urinary tract infections with systemic involvement.
Not yet recruitingCTIS2025-524703-76-00
UZ Brusselattributable to the UTI: • Temperature ≥38°C • Flank pain or costovertebral angle tenderness • Systolic blood pressure <90 mmHg without alternative cause • Significant elevation of inflammatory markers related to the UTI: o C-reactive protein concentration ≥50 mg/L, based on at least history and examination). • Bacteraemia with the same pathogen as isolated from urine culture, or possible UTI according to the diagnostic criteria of the research reference standard for UTI proposed by Bilsen et al (see reference 19 in protocol)). Systemic involvement: one or more of the following +3
Target: 264Updated: 2026-05-12