Vaniprevir

DRUG6 trials

Sponsors

Merck Sharp & Dohme LLC

Conditions

Chronic Hepatitis C InfectionHepatitis CHepatitis C, Chronic

Phase 1

Pharmacokinetics of Vaniprevir (MK-7009) and Hepatitis C Virus RNA Levels After Vaniprevir Treatment (MK-7009-029)

TerminatedNCT00954993

Merck Sharp & Dohme LLCChronic Hepatitis C Infection

Start: 2010-01-13End: 2011-03-04Updated: 2018-10-18

Phase 2

Safety and Efficacy of Vaniprevir (MK-7009) With Pegylated Interferon (Peg-IFN) and Ribavirin (RBV) in Treatment-Experienced Hepatitis C Virus (HCV) Participants (MK-7009-009)

CompletedNCT00704405

Merck Sharp & Dohme LLCHepatitis C, Chronic

Start: 2009-03-27End: 2012-09-10Updated: 2018-10-09

A Study of Safety and Efficacy of Vaniprevir Administered With Pegylated-Interferon and Ribavirin in Japanese Participants With Chronic Hepatitis C Infection (7009-016)

CompletedNCT00880763

Merck Sharp & Dohme LLCHepatitis C

Start: 2009-04-20End: 2012-02-23Updated: 2018-10-09

Phase 3

Vaniprevir Administered With Pegylated-interferon and Ribavirin in Japanese Treatment-Naïve Chronic Hepatitis C Participants (MK-7009-043)

CompletedNCT01370642

Merck Sharp & Dohme LLCHepatitis C, Chronic

Start: 2011-06-27End: 2014-03-17Updated: 2018-10-18

Study of Vaniprevir Plus PegIntron®/Ribavirin in Japanese Participants With Chronic Hepatitis C Who Relapsed After Treatment (MK-7009-044)

CompletedNCT01405937

Merck Sharp & Dohme LLCHepatitis C, Chronic

Start: 2011-08-29End: 2013-03-12Updated: 2018-10-18

Vaniprevir Plus PegIntron®/Ribavirin in Japanese Participants With Chronic Hepatitis C Who Are Non-responders to Previous Treatment (MK-7009-045)

CompletedNCT01405560

Merck Sharp & Dohme LLCHepatitis C, Chronic

Start: 2011-09-02End: 2013-03-29Updated: 2018-10-18

Related Papers

HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials

Antiviral Research2016-03-042 citations

Vaniprevir plus peginterferon alfa‐2b and ribavirin in treatment‐experienced Japanese patients with hepatitis C virus genotype 1 (GT1b) infection: Phase 3 studies

Journal of Gastroenterology and Hepatology2016-03-034 citations

Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study.

2015-09-2515 citations

Vaniprevir plus peginterferon alfa-2a and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase II study.

2014-08-1311 citations

Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis.

2013-10-1018 citations