valspodar

DRUG8 trials

Sponsors

Eastern Cooperative Oncology Group, National Cancer Institute (NCI), City of Hope Medical Center, SWOG Cancer Research Network, Leukemia Research Fund

Conditions

Adult Acute Basophilic LeukemiaAdult Acute Eosinophilic LeukemiaAdult Acute Erythroid Leukemia (M6)Adult Acute Megakaryoblastic Leukemia (M7)Adult Acute Minimally Differentiated Myeloid Leukemia (M0)Adult Acute Monoblastic Leukemia (M5a)Adult Acute Monoblastic Leukemia and Acute Monocytic Leukemia (M5)Adult Acute Monocytic Leukemia (M5b)

Phase 1

Combination Chemotherapy Plus PSC-833 in Treating Children With Refractory or Relapsed Acute Leukemia

CompletedNCT00002912

National Cancer Institute (NCI)Leukemia

Start: 1997-01-31Updated: 2013-02-01

Phase 2

Drug Resistance Inhibition in Treating Women With Recurrent or Metastatic Breast Cancer

CompletedNCT00002826

Eastern Cooperative Oncology GroupBreast Cancer

Start: 1997-08-14Target: 36Updated: 2023-06-07

S9918 PSC 833, Daunorubicin, and Cytarabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

CompletedNCT00004217

SWOG Cancer Research NetworkLeukemia

Start: 2000-02-29End: 2006-03-31Target: 55Updated: 2015-03-06

Paclitaxel With or Without PSC 833 in Treating Patients With Metastatic Breast Cancer

CompletedNCT00002937

City of Hope Medical CenterBreast Cancer

Start: 1996-06-30End: 2005-11-30Target: 70Updated: 2010-01-06

Phase 3

Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

CompletedNCT00005823

Leukemia Research FundLeukemia, Myelodysplastic/Myeloproliferative Neoplasms, Myelodysplastic Syndromes

Start: 1998-12-31End: 2007-12-31Target: 2000Updated: 2013-12-18

Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia

CompletedNCT00006363

National Cancer Institute (NCI)Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Erythroid Leukemia (M6) +30

Start: 2000-11-30Updated: 2013-06-04

Combination Chemotherapy With or Without PSC 833 in Treating Patients With Relapsed or Refractory Multiple Myeloma

CompletedNCT00002878

Eastern Cooperative Oncology GroupMultiple Myeloma and Plasma Cell Neoplasm

Start: 1997-06-30Updated: 2023-06-15

Combination Chemotherapy With or Without Valspodar in Treating Patients With Previously Untreated Acute Myeloid Leukemia

CompletedNCT00003190

National Cancer Institute (NCI)Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a) +12

Start: 1998-01-31Updated: 2013-06-04

Related Papers

A precision medicine classification for treatment of acute myeloid leukemia in older patients.

2021-06-2311 citations

P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808.

2010-06-0393 citations