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Valproic Acid (VPA)

DRUG8 trials

Sponsors

M.D. Anderson Cancer Center, University of Utah, Hospital Universitari de Bellvitge, Kimberly S Jones, National Cancer Institute, Naples

Conditions

Acute Myelogenous LeukemiaAstrocytoma, IDH-Mutant, Grade 4Breast CancerColorectal Cancer MetastaticGlioblastomaGrand Mal Status EpilepticusLeukemiaMigraine in Children

Phase 2

Azacytidine With Valproic Acid Versus Ara-C in Acute Myeloid Leukemia (AML)/ Myelodysplastic Syndrome (MDS) Patients
CompletedNCT00382590
M.D. Anderson Cancer CenterAcute Myelogenous Leukemia, Leukemia, Myelodysplastic Syndrome
Start: 2005-08-31End: 2008-02-29Updated: 2012-08-07
Valproic Acid in Ambulant Adults With Spinal Muscular Atrophy
CompletedNCT00481013
University of UtahSpinal Muscular Atrophy
Start: 2007-07-31End: 2010-11-30Updated: 2016-12-06
Study of Valproic Acid (VPA) vs Placebo to Shorten Time of Indwelling Pleural Catheter
TerminatedNCT01900730
M.D. Anderson Cancer CenterBreast Cancer
Start: 2014-07-31End: 2018-06-01Updated: 2020-02-25
Valproic Acid and Dihydroergotamine as Abortive Therapy in Pediatric Migraine
TerminatedNCT03885154
Kimberly S JonesMigraine in Children
Start: 2017-10-03End: 2019-03-19Updated: 2021-10-07
ValproIc Acid to Potentiate Anti-EGFR Treatment Efficacy and Prevent/Revert Resistance in Colorectal Cancer
RecruitingNCT06714357
National Cancer Institute, NaplesColorectal Cancer Metastatic
Start: 2025-03-12End: 2027-06-20Target: 130Updated: 2025-12-17
Valproic AcId for Traumatic BRAin INjury Trial
Not yet recruitingNCT07166393
Northwestern UniversityModerate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury
Start: 2027-05-01End: 2031-12-01Target: 432Updated: 2026-08-13
VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent Glioma
RecruitingNCT07831369
Inova Health Care ServicesAstrocytoma, IDH-Mutant, Grade 4, Glioblastoma
Start: 2026-09-04End: 2030-12-30Target: 52Updated: 2026-09-21

Phase 3

Refractory Status Epilepticus Treatment Study
CompletedNCT01586208
Hospital Universitari de BellvitgeGrand Mal Status Epilepticus, Non-convulsive Status Epilepticus
Start: 2010-01-31End: 2012-10-31Updated: 2013-03-12

Related Papers

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial.
2025-12-20
SMA CARNI-VAL trial part I: double-blind, randomized, placebo-controlled trial of L-carnitine and valproic acid in spinal muscular atrophy.
2010-08-19116 citations