Vagifem

DRUG5 trials

Sponsors

Polly A. Niravath, MD, Fred Hutchinson Cancer Center, Susan Tannenbaum, University Hospitals Cleveland Medical Center, University of California, Irvine

Conditions

Atrophy of VaginaBreast CancerDyspareunia (Female)EstrogenEstrogen Receptor Positive Breast CancerHypoestrogenismMenopausePelvic Floor Disorders

Phase 2

REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy

Active, not recruitingNCT01984138

Polly A. Niravath, MDBreast Cancer, Estrogen Receptor Positive Breast Cancer

Start: 2013-09-01End: 2026-06-01Updated: 2026-01-28

Phase 3

The Vaginal Health Trial

CompletedNCT02516202

Fred Hutchinson Cancer CenterAtrophy of Vagina, Dyspareunia (Female), Menopause

Start: 2016-04-30End: 2017-07-31Updated: 2018-07-12

Phase 4

Patient Adherence to Premarin Versus Vagifem Therapy After Female Pelvic Reconstructive Surgery

WithdrawnNCT02860897

University Hospitals Cleveland Medical CenterEstrogen, Menopause, Pelvic Floor Disorders +1

Start: 2016-07-31End: 2017-07-31Updated: 2018-05-02

Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections

Active, not recruitingNCT06353269

University of California, IrvineHypoestrogenism, Recurrent Urinary Tract Infection

Start: 2024-06-14End: 2027-09-01Target: 111Updated: 2026-06-11

Unknown Phase

Trial of Vaginal Estrogen for Urogenital Symptom Relief in Women on Aromatase Inhibitors

CompletedNCT02528383

Susan TannenbaumBreast Cancer

Start: 2015-08-31End: 2017-05-31Updated: 2017-09-18

Related Papers

Association of Vaginal Estradiol Tablet With Serum Estrogen Levels in Women Who Are Postmenopausal

JAMA Network Open2022-11-1420 citations

Impact of Topical Interventions on the Vaginal Microbiota and Metabolome in Postmenopausal Women

JAMA Network Open2022-03-3027 citations

Comparison of the Vaginal Microbiota in Postmenopausal Black and White Women

The Journal of Infectious Diseases2020-12-1913 citations

Sexual frequency and pain in a randomized clinical trial of vaginal estradiol tablets, moisturizer, and placebo in postmenopausal women

Menopause The Journal of The North American Menopause Society2019-04-1529 citations

Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms

JAMA Internal Medicine2018-03-19176 citations