Upon relapse, immunosuppressive drugs are withdrawn. If necessary, cytoreductive chemotherapy may be administered before adoptive immunotherapy. In the absence of unacceptable toxicity due to cessati
Sponsors
Aichi Cancer Center
Conditions
1) RAEB, CMML 2) AML or ALL in induction failure or beyond first remission 3) Ph/p190-positive ALL at any stage 4) imatinib-resistant CML
Phase 1
Phase I/II study of adoptive immunotherapy using cytotoxic T cells specific for minor histocompatibility antigen restricted to hematopoietic cells for patients with high-risk leukemia that relapsed following allogeneic hematopoietic stem cell transplantation
JPRN-C000000162
Start: 2004-04-01Target: 30Updated: 2026-06-29
Phase I/II study of adoptive immunotherapy using predetermined minor histocompatibility antigen-specific cytotoxic T cells for patients with high-risk leukemia that relapsed following allogeneic hematopoietic stem cell transplantation.
JPRN-C000000161
Start: 2003-10-01Target: 30Updated: 2026-06-29