Two cycles of SMILE chemotherapy consisting from steroid, methotrexate, ifosfamide, L-asparaginase, and etoposide.

3 trials

Sponsors

NK-cell Tumor Study Group

Conditions

Mature T cell lymphomaextranodal NK/T-cell lymphoma, nasal typeextranodal NK/T-cell lymphoma, nasal type or cytological diagnosis of aggressive NK-cell leukemia according to the WHO Classification

Phase 1

Phase I study of SMILE chemotherapy for advanced-stage or relapsed/refractory extranodal NK/T-cell lymphoma/leukemia(NK-SMILE-P1)

Active, not recruitingJPRN-C000000018

NK-cell Tumor Study Groupextranodal NK/T-cell lymphoma, nasal type or cytological diagnosis of aggressive NK-cell leukemia according to the WHO Classification

Start: 2005-07-01Target: 24Updated: 2026-06-29

Phase 2

Phase II study of SMILE chemotherapy for stage IV or relapsed/refractory extranodal NK/T-cell lymphoma

Active, not recruitingJPRN-UMIN000000712

NK-cell Tumor Study Groupextranodal NK/T-cell lymphoma, nasal type

Start: 2007-07-01Target: 28Updated: 2026-06-29

Unknown Phase

Phase II study of SMILE chemotherapy for relapsed/refractory mature T-cell lymphoma

Active, not recruitingJPRN-UMIN000002747

NK-cell Tumor Study GroupMature T cell lymphoma

Start: 2009-11-01Target: 42Updated: 2026-06-29