TS-142

DRUG8 trials

Sponsors

Taisho Pharmaceutical R&D Inc., Taisho Pharmaceutical Co., Ltd.

Conditions

Healthy SubjectsHealthy VolunteersInsomnia DisorderPatients with InsomniaPatients with Mild Obstructive Sleep Apnea Hypopnea

Phase 1

A Single Ascending and Repeated Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TS-142 in Healthy Participants

CompletedNCT04464239

Taisho Pharmaceutical R&D Inc.Healthy Volunteers

Start: 2020-09-14End: 2021-01-21Updated: 2021-02-10

Drug-drug Interaction Study with TS-142 in Healthy Adult Subjects (concomitant Administration of Itraconazole)

CompletedNCT04557163

Taisho Pharmaceutical Co., Ltd.Healthy Subjects

Start: 2020-10-13End: 2020-11-14Updated: 2025-02-28

A Study to Evaluate Next Day Effects of TS-142 on Driving Performance in Healthy Subjects

CompletedNCT04696952

Taisho Pharmaceutical Co., Ltd.Healthy Subjects

Start: 2021-01-16End: 2022-01-05Updated: 2025-02-28

A Clinical Pharmacology Study of TS-142 in Patients with Obstructive Sleep Apnea Hypopnea.

CompletedNCT04746105

Taisho Pharmaceutical Co., Ltd.Patients with Mild Obstructive Sleep Apnea Hypopnea

Start: 2021-02-24End: 2021-10-30Updated: 2025-02-28

A QT/QTc Evaluation Study of TS-142 in Healthy Adult Subjects

CompletedNCT04873323

Taisho Pharmaceutical Co., Ltd.Healthy Subjects

Start: 2021-06-07End: 2021-09-28Updated: 2025-02-28

A Study to Investigate the Next-day Residual Effects of TS-142 in Healthy Elderly Subjects

CompletedNCT05819710

Taisho Pharmaceutical Co., Ltd.Healthy Subjects

Start: 2023-05-15End: 2023-08-25Updated: 2025-02-28

Phase 2

Late Phase II Study of TS-142 in Patients with Insomnia

CompletedNCT04469023

Taisho Pharmaceutical Co., Ltd.Patients with Insomnia

Start: 2020-09-09End: 2021-11-16Updated: 2025-02-28

Early Phase 2 Clinical Study of TS-142 in Patients with Insomnia Disorder

CompletedNCT04573725

Taisho Pharmaceutical Co., Ltd.Insomnia Disorder

Start: 2017-07-07End: 2019-02-13Updated: 2025-02-28

Related Papers

Comparison of next-morning residual effects by bedtime administration of vornorexant and zopiclone in healthy older participants: postural stability, neuropsychological functions, and subjective sleepiness in a randomized clinical study

Psychopharmacology2026-05-23

Effects of TS-142, a novel dual orexin receptor antagonist, on sleep in patients with insomnia: a randomized, double-blind, placebo-controlled phase 2 study

Psychopharmacology2022-03-1724 citations