Truxima 100 mg concentrate for solution for infusion
Sponsors
University Hospital Of Ulm AöR, ADC Therapeutics S.A., ADC Therapeutics S.A., Regeneron Pharmaceuticals Inc., Amsterdam UMC, ADC Therapeutics S.A.
Conditions
ANCA VasculitisB-cell Non-Hodgkin's lymphomaDiffuse Large B-Cell Lymphoma (DLBCL)Diffuse large B-cell LymphomaFollicular LymphomaFollicular lymphomaLupus ErythematosusMarginal Zone Lymphoma
Phase 1
Phase 2
A Phase 2 Open-label Study of Loncastuximab Tesirine in Combination with Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Patients with Diffuse Large B-cell Lymphoma (DLBCL) (LOTIS-9)
CompletedCTIS2022-501601-12-00
Start: 2023-05-22End: 2023-11-28Target: 28Updated: 2023-10-25
(Synbiose-2 )Synergetic B-cell immunomodulation in SLE – 2 nd study
RecruitingCTIS2023-507867-20-00
Start: 2018-10-04Target: 30Updated: 2024-08-28
Copanlisib and Rituximab in Marginal Zone Lymphoma Patients - A MULTICENTER OPEN LABEL SINGLE-ARM PHASE II STUDY (COUP-1)
Active, not recruitingCTIS2022-500674-34-00
Start: 2019-11-04Target: 36Updated: 2025-04-30
Phase 3
A Phase 3, Open Label, Randomized Study to Compare the Efficacy and Safety of Odronextamab (REGN1979), an Anti-CD20 x Anti-CD3 Bispecific Antibody, in Combination with Lenalidomide Versus Rituximab in Combination with Lenalidomide in Relapsed/Refractory Participants with Follicular Lymphoma and Marginal Zone Lymphoma (OLYMPIA-5)
RecruitingCTIS2022-503092-28-00
Start: 2024-01-08Target: 234Updated: 2026-01-27
A PHASE 3, OPEN-LABEL, RANDOMIZED STUDY TO COMPARE THE EFFICACY AND SAFETY OF ODRONEXTAMAB (REGN1979), AN ANTI-CD20 X ANTI-CD3 BISPECIFIC ANTIBODY, VERSUS INVESTIGATOR’S CHOICE IN PREVIOUSLY UNTREATED PARTICIPANTS WITH FOLLICULAR LYMPHOMA (OLYMPIA-1)
RecruitingCTIS2022-502660-20-00
Start: 2024-01-23Target: 255Updated: 2026-01-27
A Phase 3, Open-Label, Randomized Study To Compare the Efficacy and Safety of Odronextamab (REGN1979), an Anti-CD20 x Anti-CD3 Bispecific Antibody, Combined with Chemotherapy versus Rituximab Combined with Chemotherapy in Previously Untreated Participants with Follicular Lymphoma (OLYMPIA-2)
RecruitingCTIS2022-502113-28-00
Start: 2024-02-01Target: 220Updated: 2026-01-27
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Tafasitamab Plus Lenalidomide in Addition to Rituximab Versus Lenalidomide in Addition to Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma Grade 1 to 3a or R/R Marginal Zone Lymphoma
Active, not recruitingCTIS2023-504684-16-00
Start: 2021-06-05Target: 345Updated: 2025-10-02
A Phase 3 Randomized Study of Loncastuximab Tesirine Combined with Rituximab Versus Immunochemotherapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (LOTIS-5)
Active, not recruitingCTIS2023-503916-33-00
Start: 2021-03-24Target: 277Updated: 2025-07-17
A Phase 3, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination with Rituximab and Lenalidomide (R2) compared to R2 in Subjects with Relapsed or Refractory Follicular Lymphoma (EPCORE™ FL-1)
Active, not recruitingCTIS2023-505628-67-00
Start: 2022-10-28Target: 280Updated: 2025-12-19
A Phase 3, Randomized, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination with R-CHOP Compared to R-CHOP in Subjects with Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) (EPCORE DLBCL-2)
RecruitingCTIS2023-505277-32-00
Start: 2023-01-26Target: 435Updated: 2025-12-11
A Phase 3, Multicenter, Randomized, Open-Label Trial to Evaluate the Safety and Efficacy of Epcoritamab + Rituximab and Lenalidomide (R2) compared to Chemoimmunotherapy in Previously Untreated Follicular Lymphoma (EPCORE™FL-2)
Active, not recruitingCTIS2023-506906-38-00
Start: 2024-05-23Target: 357Updated: 2026-01-20
SYMPHONY-1: A PHASE 1B/3 DOUBLE-BLIND, RANDOMIZED, ACTIVE-CONTROLLED, 3-STAGE, BIOMARKER ADAPTIVE STUDY OF TAZEMETOSTAT OR PLACEBO IN COMBINATION WITH LENALIDOMIDE PLUS RITUXIMAB IN SUBJECTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
RecruitingCTIS2024-510690-16-00
Start: 2022-01-31Target: 226Updated: 2025-06-26
A Phase 3, Multicenter, Randomized, Open-Label Study of Epcoritamab Plus Lenalidomide Compared to Rituximab Plus Gemcitabine and Oxaliplatin in Participants with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
RecruitingCTIS2024-510965-41-00
Start: 2024-09-03Target: 116Updated: 2025-12-15
Phase 4
Noisy Rebels; Non-inferiority study of rituximab compared to ocrelizumab in relapsing MS
Active, not recruitingCTIS2022-502664-21-00
Start: 2023-05-01Target: 200Updated: 2025-10-14
Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-Guided Dose Reduction in Patients with Rheumatoid Arthritis: The RITUXERA Trial.
RecruitingCTIS2023-506638-59-01
Start: 2024-01-09Target: 134Updated: 2025-08-27
Evaluating, clinical and immunological effects of rituximab with cyclophosphamide compared to rituximab alone in AAV patients (The ENDURRANCE-1 Study)
RecruitingCTIS2023-507868-39-00
Start: 2019-05-03Target: 100Updated: 2025-08-11