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Trospium Chloride

DRUG9 trials

Sponsors

Allergan, NICHD Pelvic Floor Disorders Network, University of North Carolina, Chapel Hill, Karuna Therapeutics, Mansoura University

Conditions

Accidental FallsCognitive FunctionElderlyHealthy VolunteersMental CompetencyOveractive BladderPharmacokineticsQuality of Life

Early Phase 1

Comparative Effectiveness of Initial OAB Treatment Options Among Older Women at High Risk of Falls
Active, not recruitingNCT05880862
The University of Texas Medical Branch, GalvestonAccidental Falls, Urinary Bladder, Overactive, Urinary Incontinence
Start: 2023-09-28End: 2025-12-31Target: 48Updated: 2025-11-21

Phase 1

Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium
CompletedNCT02831231
Karuna TherapeuticsSchizophrenia
Start: 2016-09-07End: 2016-10-28Updated: 2017-04-19
A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, and to Explore the Effect of Food After Multiple Doses of Selected Prototypes in Healthy Adult Participants
RecruitingNCT07063342
Bristol-Myers SquibbHealthy Volunteers
Start: 2025-06-27End: 2026-08-15Target: 72Updated: 2025-12-19

Phase 3

Anticholinergic vs. Botox Comparison Study
CompletedNCT01166438
NICHD Pelvic Floor Disorders NetworkOveractive Bladder, Urge Urinary Incontinence
Start: 2010-03-31End: 2012-05-31Updated: 2018-05-02

Phase 4

Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART) Trial
CompletedNCT00863551
AllerganElderly, Overactive Bladder, Pharmacokinetics
Start: 2009-04-30End: 2009-08-31Updated: 2016-02-26
Efficacy of Sanctura XR (Trospium Chloride) for Reducing Overactive Bladder Symptoms in Female Subjects Refractory to Detrol LA (Tolterodine Tartrate Extended Release) Daily
CompletedNCT01089751
AllerganOveractive Bladder
Start: 2010-03-31End: 2012-06-30Updated: 2013-09-26
Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART-II) Trial
CompletedNCT01178827
AllerganOveractive Bladder
Start: 2010-08-31End: 2011-03-31Updated: 2016-02-26
The Effect of Anticholinergics on Cognitive Function in the Elderly
CompletedNCT01922115
University of North Carolina, Chapel HillCognitive Function, Mental Competency, Urinary Bladder, Overactive
Start: 2013-06-30End: 2015-06-30Updated: 2017-03-22

Unknown Phase

Trospium Chloride vs Tamsulosin in Treatment of Ureteral Stent Related Symptoms:
SuspendedNCT03709992
Mansoura UniversityQuality of Life, Ureter Obstruction, Ureter Stone
Start: 2020-12-18End: 2024-11-01Target: 200Updated: 2023-10-12

Related Papers

Complete genome sequences of <i>Aerococcus loyolae</i> ATCC TSD-300 <sup>T</sup> , <i>Aerococcus mictus</i> ATCC TSD-301 <sup>T</sup> , and <i>Aerococcus tenax</i> ATCC TSD-302 <sup>T</sup>
Microbiology Resource Announcements2024-04-232 citations
Comparative effectiveness of pelvic floor muscle training, mirabegron, and trospium among older women with urgency urinary incontinence and high fall risk: a feasibility randomized clinical study.
2024-01-04
Evidence of trospium’s ability to mitigate cholinergic adverse events related to xanomeline: phase 1 study results
Psychopharmacology2023-04-1054 citations
Safety and tolerability of KarXT (xanomeline-trospium) in a phase 2, randomized, double-blind, placebo-controlled study in patients with schizophrenia.
2022-12-0344 citations
Anticholinergic therapy vs. onabotulinumtoxina for urgency urinary incontinence.
2012-10-04143 citations