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Trixeo Aerosphere 5 micrograms/7.2 micrograms/160 micrograms pressurised inhalation

DRUG7 trials

Sponsors

AstraZeneca AB, Astrazeneca AB, Centre Hospitalier Universitaire De Lille

Conditions

Chronic Obstructive Pulmonary DiseaseChronic Obstructive Pulmonary Disease (COPD)Impact of inhaled BGF 160 on complexity and variability of tidal breathing and oscillatory mechanics in stable COPD patientModerate to Severe Chronic Obstructive Pulmonary Disease(COPD)Severe and inadequately controlled asthma

Phase 3

A Double Blind, Multicentre, Randomised Three-Period, Three-Treatment, Cross-Over Study To Evaluate The Effect of BGF MDI, BFF MDI and Placebo MDI on Exercise Parameters In Participants with Chronic Obstructive Pulmonary Disease (ATHLOS)
CompletedCTIS2022-502274-16-00
AstraZeneca ABChronic Obstructive Pulmonary Disease
Start: 2023-10-19End: 2026-01-13Target: 160Updated: 2025-11-14
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter 24 to 52 Week Variable Length Study to Assess the Efficacy and Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler (MDI) Relative to Budesonide and Formoterol Fumarate MDI and Symbicort® pressurised MDI in Adult and Adolescent Participants with Inadequately Controlled Asthma (KALOS)
CompletedCTIS2023-505787-11-00
AstraZeneca ABSevere and inadequately controlled asthma
Start: 2021-04-29End: 2025-03-18Target: 678Updated: 2025-05-05
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter 24 to 52 Week Variable Length Study to Assess the Efficacy and Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler (MDI) Relative to Budesonide and Formoterol Fumarate MDI and Symbicort® pMDI in Adult and Adolescent Participants with Inadequately Controlled Asthma (LOGOS)
CompletedCTIS2023-505786-88-00
Astrazeneca ABSevere and inadequately controlled asthma
Start: 2021-04-25End: 2025-03-19Target: 441Updated: 2025-03-21
A Randomised, Placebo-Controlled, Double-Blind, Multi-Centre, 4-week, 3-way Crossover Pharmacodynamic Study to Assess the Equivalence of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) Delivered by MDI HFO Compared with BGF Delivered by MDI HFA in Participants with Chronic Obstructive Pulmonary Disease
CompletedCTIS2023-506565-57-00
Astrazeneca ABModerate to Severe Chronic Obstructive Pulmonary Disease(COPD)
Start: 2024-06-21End: 2025-07-14Target: 49Updated: 2025-08-11
A Randomized, Double-Blind, Parallel Group, Multi-Center, Phase III Study to Assess the Efficacy of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered-Dose Inhaler Relative to Glycopyrronium and Formoterol Fumarate MDI on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease (THARROS)
RecruitingCTIS2023-507407-59-00
Astrazeneca ABChronic Obstructive Pulmonary Disease (COPD)
Start: 2024-07-04Target: 1365Updated: 2026-01-19

Phase 4