Trimetrexate glucuronate
Sponsors
National Institute of Allergy and Infectious Diseases (NIAID), U.S. Bioscience, Memorial Sloan Kettering Cancer Center, University of Southern California, Grupo Oncologico Cooperativo del Sur
Conditions
Colorectal CancerHIV InfectionsLeukemiaLymphomaPancreatic CancerPneumonia, Pneumocystis CariniiSarcoma
Phase 1
Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia
CompletedNCT00002120
Target: 20Updated: 2005-06-24
A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP
CompletedNCT00000998
End: 1989-04-30Target: 50Updated: 2021-11-04
Methotrexate, Trimetrexate Glucuronate, and Leucovorin in Treating Patients With Refractory or Recurrent Osteosarcoma
CompletedNCT00119301
Start: 2005-04-30Target: 18Updated: 2013-01-17
Phase 2
Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia, Osteosarcoma, or Non-Hodgkin's Lymphoma
CompletedNCT00002738
Start: 1996-01-31End: 2006-06-30Target: 25Updated: 2013-03-07
Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
CompletedNCT00003446
Start: 1997-12-31End: 2005-08-31Updated: 2013-06-26
Combination Chemotherapy in Treating Patients With Advanced Cancer of the Pancreas
CompletedNCT00002955
Start: 1995-08-31End: 2006-06-30Updated: 2014-05-22
Combination Chemotherapy and Surgery in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma
CompletedNCT00003776
Start: 1998-12-31End: 2000-03-31Updated: 2013-06-21
Phase 3
An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies
CompletedNCT00000714
End: 2004-07-31Updated: 2021-10-29
A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia
CompletedNCT00000724
End: 2004-07-31Updated: 2012-12-19
A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies
CompletedNCT00001016
End: 2007-08-31Updated: 2008-09-30
Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
CompletedNCT00001014
End: 1991-09-30Target: 302Updated: 2021-11-04
Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
CompletedNCT00001013
End: 1991-09-30Target: 364Updated: 2021-11-04
Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients
TerminatedNCT00000730
End: 1989-03-31Target: 240Updated: 2021-11-03
Unknown Phase
A Study of Neutrexin Plus Leucovorin in the Treatment of Pneumocystis Carinii Pneumonia (PCP)
CompletedNCT00002434
Updated: 2005-06-24
A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With Pneumocystis Carinii Pneumonia.
CompletedNCT00002102
Updated: 2005-06-24
A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia
CompletedNCT00002317
Updated: 2005-06-24
A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia
CompletedNCT00002103
Updated: 2005-06-24