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Trigeminal Nerve Stimulation (TNS)

DEVICE4 trials

Sponsors

Santa Casa Medical School, Medical University of South Carolina, University of California, Los Angeles

Conditions

Attention Deficit Hyperactivity DisorderDepressive SymptomsFetal Alcohol Spectrum DisordersLong COVIDNicotine CravingOlfactory DisorderSmell Dysfunction

Phase 1

TNS for Major Depressive Disorder: a Phase II Randomized Controlled Trial
NCT02105376
Santa Casa Medical SchoolDepressive Symptoms
Start: 2014-05-31Target: 44Updated: 2015-05-05
TNS for Treating Nicotine Craving
NCT02178852
Santa Casa Medical SchoolNicotine Craving
Start: 2014-08-31Target: 22Updated: 2014-07-01

Phase 2

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
RecruitingNCT05855369
Medical University of South CarolinaLong COVID, Olfactory Disorder, Smell Dysfunction
Start: 2023-10-02End: 2028-05-31Target: 145Updated: 2026-04-02

Unknown Phase

Trigeminal Nerve Stimulation for Children With Prenatal Alcohol Exposure
RecruitingNCT06847165
University of California, Los AngelesAttention Deficit Hyperactivity Disorder, Fetal Alcohol Spectrum Disorders
Start: 2025-04-26End: 2026-09-30Target: 30Updated: 2026-07-16

Related Papers

Trigeminal nerve stimulation (TNS) for children with attention deficit/hyperactivity disorder and fetal alcohol spectrum disorder: Feasibility study protocol
PLoS ONE2025-08-29
CONSORT diagram.
OPAL (Open@LaTrobe) (La Trobe University)2025-08-29
SPIRIT checklist.
OPAL (Open@LaTrobe) (La Trobe University)2025-08-29
Full study protocol.
OPAL (Open@LaTrobe) (La Trobe University)2025-08-29